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dc.contributor.author
Pasqualone, Magalí
dc.contributor.author
Oberti, Tamara Gisela
dc.contributor.author
Andreetta, Héctor Alfredo
dc.contributor.author
Cortizo, Maria Susana
dc.date.available
2016-04-18T14:03:58Z
dc.date.issued
2013-04
dc.identifier.citation
Pasqualone, Magalí; Oberti, Tamara Gisela; Andreetta, Héctor Alfredo; Cortizo, Maria Susana; Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties; Springer; Journal of Materials Science: Materials In Medicine; 24; 7; 4-2013; 1683-1692
dc.identifier.issn
0957-4530
dc.identifier.uri
http://hdl.handle.net/11336/5255
dc.description.abstract
Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Liberacion Controlada
dc.subject
Membrana Transdermicas
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Copolimeros
dc.subject.classification
Ingeniería de los Materiales
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-06 15:52:43.262787-03
dc.journal.volume
24
dc.journal.number
7
dc.journal.pagination
1683-1692
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Pasqualone, Magalí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
dc.description.fil
Fil: Oberti, Tamara Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
dc.description.fil
Fil: Andreetta, Héctor Alfredo. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas; Argentina
dc.description.fil
Fil: Cortizo, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
dc.journal.title
Journal of Materials Science: Materials In Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/23588672
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs10856-013-4925-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10856-013-4925-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10856-013-4925-2
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