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dc.contributor.author
Hernández Pando, Rogelio
dc.contributor.author
Barrios Payán, Jorge
dc.contributor.author
Mata Espinosa, Dulce
dc.contributor.author
Marquina Castillo, Brenda
dc.contributor.author
Hernández Ramírez, Diego
dc.contributor.author
Bottasso, Oscar Adelmo
dc.contributor.author
Bini, Estela Isabel
dc.date.available
2018-07-17T21:20:06Z
dc.date.issued
2015-07
dc.identifier.citation
Hernández Pando, Rogelio; Barrios Payán, Jorge; Mata Espinosa, Dulce; Marquina Castillo, Brenda; Hernández Ramírez, Diego; et al.; The role of high mobility group box 1 protein (HMGB1) in the immunopathology of experimental pulmonary tuberculosis; Public Library of Science; Plos One; 10; 7; 7-2015; 1-14; e0133200
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/52536
dc.description.abstract
Background: The high mobility group box 1 (HMGB1) is the prototype of alarmin protein released by stressed or dying cells. The redox state of this protein confers different functions in the regulation of inflammation and immune response. Aim: Determine the kinetics, cellular sources and function of HMGB1 in experimental tuberculosis. Methods: BALB/c mice were infected with Mycobacterium tuberculosis strain H37Rv. At different time points, HMGB1 was quantified in bronchial lavage fluid (BALF) and in lungs was determined its cellular sources by immunohistochemistry. HMGB1 was blocked with specific antibodies or recombinant HMGB1 was administered during early or late infection. Bacilli burdens, inflammation and cytokines expression were determined. Results: The maximal concentration of HMGB1 in BALF was at day one of infection. Bronchial epithelium and macrophages were the most important sources. At day 7 to 21 the oxidized HMGB1 was predominant, while during late infection only the reduced form was seen. Blocking HMGB1 during early infection produced significant decrease of bacilli burdens and high production of pro-inflammatory cytokines, while the opposite was seen when HMGB1 was administered. Blocking HMGB1 activity or administrated it in high amounts during late infection worsening the disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hmgb1
dc.subject
Tuberculosis
dc.subject
Alarmins
dc.subject
Experimental Models
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The role of high mobility group box 1 protein (HMGB1) in the immunopathology of experimental pulmonary tuberculosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-17T13:57:59Z
dc.journal.volume
10
dc.journal.number
7
dc.journal.pagination
1-14; e0133200
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Hernández Pando, Rogelio. Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"; México
dc.description.fil
Fil: Barrios Payán, Jorge. Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"; México
dc.description.fil
Fil: Mata Espinosa, Dulce. Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"; México
dc.description.fil
Fil: Marquina Castillo, Brenda. Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"; México
dc.description.fil
Fil: Hernández Ramírez, Diego. Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"; México
dc.description.fil
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
dc.description.fil
Fil: Bini, Estela Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina. Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"; México
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0133200
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133200


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  • Articulos(IDICER) [38]
    Articulos de INSTITUTO DE INMUNOLOGIA CLINICA Y EXPERIMENTAL DE ROSARIO

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