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dc.contributor.author
Socolsky, Cecilia  
dc.contributor.author
Rates, Stella Maris K.  
dc.contributor.author
Stein, Ana Cristina  
dc.contributor.author
Asakawa, Yoshinori  
dc.contributor.author
Bardon, Alicia del Valle  
dc.date.available
2018-07-17T19:27:36Z  
dc.date.issued
2012-06  
dc.identifier.citation
Socolsky, Cecilia; Rates, Stella Maris K.; Stein, Ana Cristina; Asakawa, Yoshinori; Bardon, Alicia del Valle; Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A; American Chemical Society; Journal of Natural Products; 75; 6; 6-2012; 1007-1017  
dc.identifier.issn
0163-3864  
dc.identifier.uri
http://hdl.handle.net/11336/52491  
dc.description.abstract
Nine new terpenylated acylphloroglucinols, crassipins A-I, were isolated from the rhizomes and roots of the fern Elaphoglossum crassipes, and their structures were elucidated by analysis of spectroscopic data and chemical derivatization. The absolute configurations of some of the compounds were established by CD and VCD in combination with a quantum mechanical method. Crassipin A (1), the major acylphloroglucinol of the Et2O extract of E. crassipes, as well as its peracetylated derivative (8), displayed antidepressantlike activity in a mouse forced-swimming test when administered orally at a dose of 15 mg/kg.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Chemical Society  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Acylphloroglucinols  
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Elaphoglossum Crassipes  
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Antidepressant-Like Activity  
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Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-07-11T17:16:40Z  
dc.journal.volume
75  
dc.journal.number
6  
dc.journal.pagination
1007-1017  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Washington DC  
dc.description.fil
Fil: Socolsky, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina  
dc.description.fil
Fil: Rates, Stella Maris K.. Universidade Federal do Rio Grande do Sul; Brasil  
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Fil: Stein, Ana Cristina. Universidade Federal do Rio Grande do Sul; Brasil  
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Fil: Asakawa, Yoshinori. Tokushima Bunri University; Japón  
dc.description.fil
Fil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina  
dc.journal.title
Journal of Natural Products  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1021/np200436h  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/np200436h  

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