Artículo
More Than Just Light: Clinical Relevance of Light Perception in the Nosocomial Pathogen Acinetobacter baumannii and Other Members of the Genus Acinetobacter
Ramirez, Maria Soledad
; Müller, Gabriela Leticia
; Pérez, Jorgelina Fernanda; Golic, Adrián Ezequiel
; Mussi, María Alejandra
Fecha de publicación:
11/2015
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Photochemistry and Photobiology
ISSN:
0031-8655
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A summary of the major findings concerning light modulation in Acinetobacter baumannii, which governs aspects related to the success of this microorganism as a nosocomial pathogen, is presented. Particularly, the evidence shows that light modulates the ability of the bacteria to persist in the environment, its virulence against eukaryotic hosts and even susceptibility to certain antibiotics. The light signal is sensed through different mechanisms, in some cases involving specialized photoreceptors of the BLUF-type, whereas in others, directly by a photosensitizer molecule. We also provide new data concerning the genomic context of BLUF-domain containing proteins within the genus Acinetobacter, as well as further insights into the mechanism of light-mediated reduction in susceptibility to antibiotics. The overall information points toward light being a crucial stimulus in the lifestyle of members of the genus Acinetobacter as well as in other clinically relevant species, such as members of the ESKAPE group, playing therefore an important role in the clinical settings.
Palabras clave:
Acinetobacter
,
Clinical
,
Light
,
Resistance
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Colecciones
Articulos(CEFOBI)
Articulos de CENTRO DE EST.FOTOSINTETICOS Y BIOQUIMICOS (I)
Articulos de CENTRO DE EST.FOTOSINTETICOS Y BIOQUIMICOS (I)
Citación
Ramirez, Maria Soledad; Müller, Gabriela Leticia; Pérez, Jorgelina Fernanda; Golic, Adrián Ezequiel; Mussi, María Alejandra; More Than Just Light: Clinical Relevance of Light Perception in the Nosocomial Pathogen Acinetobacter baumannii and Other Members of the Genus Acinetobacter; Wiley Blackwell Publishing, Inc; Photochemistry and Photobiology; 91; 6; 11-2015; 1291-1301
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