Mostrar el registro sencillo del ítem
dc.contributor.author
Moreno Sastre, M.
dc.contributor.author
Pastor, M.
dc.contributor.author
Salomon, Claudio Javier
dc.contributor.author
Esquisabel, A.
dc.contributor.author
Pedraz, J. L.
dc.date.available
2018-07-17T15:32:47Z
dc.date.issued
2015-07
dc.identifier.citation
Moreno Sastre, M.; Pastor, M.; Salomon, Claudio Javier; Esquisabel, A.; Pedraz, J. L.; Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy; Oxford University Press; Journal of Antimicrobial Chemotherapy; 70; 11; 7-2015; 2945-2955
dc.identifier.issn
0305-7453
dc.identifier.uri
http://hdl.handle.net/11336/52387
dc.description.abstract
As the WHO stated, lower respiratory infections are the third leading cause of death. In addition, it is remarkable that antimicrobial resistance represents a huge threat. Thus, new therapeutic weapons are required. Among the possible alternatives, antibiotic encapsulation in nanoparticles has gained much attention in terms of improved tolerability, activity and ability to combat the resistance mechanisms of bacteria. In this regard, this reviewarticle focuses on the latest nanocarrier approaches for inhalatory therapy of antibiotics. First, the technology related to lung disposition will be reviewed. Then, nanocarrier systems will be introduced and the challenges required to perform adequate pulmonary deposition analysed. In the following part, drug delivery systems (DDSs) on the market or in clinical trials are described and, finally, new approaches of nanoparticles that have reached preclinical stage are enumerated. Altogether, this review aims at gathering together the novel nanosystems for anti-infectious therapy, underlining the potential of DDSs to improve and optimize currently available antibiotic therapies in the context of lung infections.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pulmonary Drug Delivery
dc.subject
Nanocarriers
dc.subject
Antibacterial Chemotherapy
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-17T13:55:20Z
dc.journal.volume
70
dc.journal.number
11
dc.journal.pagination
2945-2955
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Moreno Sastre, M.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
dc.description.fil
Fil: Pastor, M.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
dc.description.fil
Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
dc.description.fil
Fil: Esquisabel, A.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
dc.description.fil
Fil: Pedraz, J. L.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
dc.journal.title
Journal of Antimicrobial Chemotherapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/jac/dkv192
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jac/article/70/11/2945/2363606
Archivos asociados