Mostrar el registro sencillo del ítem

dc.contributor.author
Klein, Stefanie  
dc.contributor.author
Sommer, Anja  
dc.contributor.author
Dell'Arciprete, Maria Laura  
dc.contributor.author
Wegmann, Marc  
dc.contributor.author
Ott, Susanne  
dc.contributor.author
Distel, Luitpold V. R.  
dc.contributor.author
Neuhuber, Winfried  
dc.contributor.author
Gonzalez, Monica Cristina  
dc.contributor.author
Kryschi, Carola  
dc.date.available
2016-04-14T21:27:35Z  
dc.date.issued
2014-06  
dc.identifier.citation
Klein, Stefanie; Sommer, Anja; Dell'Arciprete, Maria Laura; Wegmann, Marc; Ott, Susanne; et al.; Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy; SciTechnol; Journal of Nanomaterials & Molecular Nanotechnology; S2; 6-2014; 1-7  
dc.identifier.issn
2324-8777  
dc.identifier.uri
http://hdl.handle.net/11336/5216  
dc.description.abstract
Our research objective is to develop superparamagnetic iron oxide nanoparticles and silicon nanoparticles as radiosensitizers for cancer therapy. After internalization by breast tumor cells and irradiation with X-rays, the nanoparticles were observed to enhance the oxidative stress in tumor cells. While silicon nanoparticles increase the reactive oxygen species production under X-ray treatment due to their incompletely oxidized surface, positively charged amino-functionalized silicon nanoparticles enhance the formation of mitochondrial reactive oxygen species formation because of their direct interaction with the mitochondrial membrane. On the other hand, uncoated and citrate-coated superparamagnetic iron oxide nanoparticles were found to increase the reactive oxygen species formation in X-ray treated tumor cells via two particular surface features, being, first, the leakage of iron ions and second, the catalytic activity of nanoparticle surfaces. Both may initiate the Haber-Weiss and Fenton reaction.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
SciTechnol  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Silicon Nanoparticles  
dc.subject
Superparamagnetic Iron Oxide Nanoparticles  
dc.subject
Radiation Therapy  
dc.subject
Reactive Oxygen Species Generation  
dc.subject.classification
Nano-materiales  
dc.subject.classification
Nanotecnología  
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-05-06 15:52:43.262787-03  
dc.journal.volume
S2  
dc.journal.pagination
1-7  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Los Angeles  
dc.description.fil
Fil: Klein, Stefanie. Universitat Erlangen-Nuremberg; Alemania  
dc.description.fil
Fil: Sommer, Anja. Universitat Erlangen-Nuremberg; Alemania  
dc.description.fil
Fil: Dell'Arciprete, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina  
dc.description.fil
Fil: Wegmann, Marc. Universitat Erlangen-Nuremberg; Alemania  
dc.description.fil
Fil: Ott, Susanne. Universitat Erlangen-Nuremberg; Alemania  
dc.description.fil
Fil: Distel, Luitpold V. R.. Universitat Erlangen-Nuremberg; Alemania  
dc.description.fil
Fil: Neuhuber, Winfried . Universitat Erlangen-Nuremberg; Alemania  
dc.description.fil
Fil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina  
dc.description.fil
Fil: Kryschi, Carola. Universitat Erlangen-Nuremberg; Alemania  
dc.journal.title
Journal of Nanomaterials & Molecular Nanotechnology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://scitechnol.com/oxidized-silicon-nanoparticles-and-iron-oxide-nanoparticles-for-radiation-therapy-3DsQ.php?article_id=2169  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4172/2324-8777.S2-002  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.4172/2324-8777.S2-002