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dc.contributor.author
Klein, Stefanie
dc.contributor.author
Sommer, Anja
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Dell'Arciprete, Maria Laura
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Wegmann, Marc
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Ott, Susanne
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Distel, Luitpold V. R.
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Neuhuber, Winfried
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Gonzalez, Monica Cristina
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Kryschi, Carola
dc.date.available
2016-04-14T21:27:35Z
dc.date.issued
2014-06
dc.identifier.citation
Klein, Stefanie; Sommer, Anja; Dell'Arciprete, Maria Laura; Wegmann, Marc; Ott, Susanne; et al.; Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy; SciTechnol; Journal of Nanomaterials & Molecular Nanotechnology; S2; 6-2014; 1-7
dc.identifier.issn
2324-8777
dc.identifier.uri
http://hdl.handle.net/11336/5216
dc.description.abstract
Our research objective is to develop superparamagnetic iron oxide nanoparticles and silicon nanoparticles as radiosensitizers for cancer therapy. After internalization by breast tumor cells and irradiation with X-rays, the nanoparticles were observed to enhance the oxidative stress in tumor cells. While silicon nanoparticles increase the reactive oxygen species production under X-ray treatment due to their incompletely oxidized surface, positively charged amino-functionalized silicon nanoparticles enhance the formation of mitochondrial reactive oxygen species formation because of their direct interaction with the mitochondrial membrane. On the other hand, uncoated and citrate-coated superparamagnetic iron oxide nanoparticles were found to increase the reactive oxygen species formation in X-ray treated tumor cells via two particular surface features, being, first, the leakage of iron ions and second, the catalytic activity of nanoparticle surfaces. Both may initiate the Haber-Weiss and Fenton reaction.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SciTechnol
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Silicon Nanoparticles
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Superparamagnetic Iron Oxide Nanoparticles
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Radiation Therapy
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Reactive Oxygen Species Generation
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-06 15:52:43.262787-03
dc.journal.volume
S2
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Los Angeles
dc.description.fil
Fil: Klein, Stefanie. Universitat Erlangen-Nuremberg; Alemania
dc.description.fil
Fil: Sommer, Anja. Universitat Erlangen-Nuremberg; Alemania
dc.description.fil
Fil: Dell'Arciprete, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
dc.description.fil
Fil: Wegmann, Marc. Universitat Erlangen-Nuremberg; Alemania
dc.description.fil
Fil: Ott, Susanne. Universitat Erlangen-Nuremberg; Alemania
dc.description.fil
Fil: Distel, Luitpold V. R.. Universitat Erlangen-Nuremberg; Alemania
dc.description.fil
Fil: Neuhuber, Winfried . Universitat Erlangen-Nuremberg; Alemania
dc.description.fil
Fil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
dc.description.fil
Fil: Kryschi, Carola. Universitat Erlangen-Nuremberg; Alemania
dc.journal.title
Journal of Nanomaterials & Molecular Nanotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://scitechnol.com/oxidized-silicon-nanoparticles-and-iron-oxide-nanoparticles-for-radiation-therapy-3DsQ.php?article_id=2169
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4172/2324-8777.S2-002
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.4172/2324-8777.S2-002


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