Artículo
Transcriptional regulation of the protein kinase a subunits in Saccharomyces cerevisiae during fermentative growth
Galello, Fiorella Ariadna
; Pautasso, María Constanza
; Reca, Sol Rita
; Cañonero, Luciana
; Portela, Paula
; Moreno, Silvia Margarita
; Rossi, Silvia Graciela
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Fecha de publicación:
12/2017
Editorial:
John Wiley & Sons Ltd
Revista:
Yeast
ISSN:
0749-503X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Yeast cells can adapt their growth in response to the nutritional environment. Glucose is the favourite carbon source of Saccharomyces cerevisiae, which prefers a fermentative metabolism despite the presence of oxygen. When glucose is consumed, the cell switches to the aerobic metabolism of ethanol, during the so-called diauxic shift. The difference between fermentative and aerobic growth is in part mediated by a regulatory mechanism called glucose repression. During glucose derepression a profound gene transcriptional reprogramming occurs and genes involved in the utilization of alternative carbon sources are expressed. Protein kinase A (PKA) controls different physiological responses following the increment of cAMP as a consequence of a particular stimulus. cAMP–PKA is one of the major pathways involved in the transduction of glucose signalling. In this work the regulation of the promoters of the PKA subunits during respiratory and fermentative metabolism are studied. It is demonstrated that all these promoters are upregulated in the presence of glycerol as carbon source through the Snf1/Cat8 pathway. However, in the presence of glucose as carbon source, the regulation of each PKA promoter subunits is different and only TPK1 is repressed by the complex Hxk2/Mig1 in the presence of active Snf1.
Palabras clave:
Bcy1
,
Carbon Source
,
Pka
,
Saccharomyces Cerevisiae
,
Tpks
,
Transcription Regulation
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Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Galello, Fiorella Ariadna; Pautasso, María Constanza; Reca, Sol Rita; Cañonero, Luciana; Portela, Paula; et al.; Transcriptional regulation of the protein kinase a subunits in Saccharomyces cerevisiae during fermentative growth; John Wiley & Sons Ltd; Yeast; 34; 12; 12-2017; 495-508
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