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dc.contributor.author
Joo Turoni, Claudio Martín
dc.contributor.author
Chaila, Zulema
dc.contributor.author
Chahla, Rossana
dc.contributor.author
Bazan de Casella, María Cristina del Valle
dc.contributor.author
Peral, Maria de Los Angeles
dc.date.available
2018-07-11T20:08:30Z
dc.date.issued
2016-07
dc.identifier.citation
Joo Turoni, Claudio Martín; Chaila, Zulema; Chahla, Rossana; Bazan de Casella, María Cristina del Valle; Peral, Maria de Los Angeles; Vascular Function in Children with Low Birthweight and Its Relationship with Early Markers of Cardiovascular Risk; Karger; Hormone Research in Paediatrics; 85; 6; 7-2016; 396-405
dc.identifier.issn
1663-2818
dc.identifier.uri
http://hdl.handle.net/11336/51791
dc.description.abstract
Low birthweight (LBW) increases the risk of developing cardiovascular diseases (CVD). Few studies have established its impact at early ages. Aims: To study endothelial function (EF) and arterial stiffness (AS) and their relationship to early markers of CVD risk in children with LBW. Methods: In children with LBW (4-6 years; n = 53), anthropometric, haemodynamic and laboratory parameters, including HOMA-IR, hs-CRP, adiponectin and leptin, were determined. EF and AS were evaluated by digital pulse plethysmography. Data were compared with a control group (n = 33). Results: In both groups, anthropometric parameters remained within normal limits. Insulin and HOMA-IR had normal values, but they were significantly augmented in LBW children. LBW children showed higher leptin and hs-CRP levels than the control group. The LBW group had decreased EF (37.5 ± 5.6%) compared with the control group (75.0 ± 11.9%; p < 0.01), however without differences in AS. In LBW children, EF was negatively correlated with waist circumference, leptin, hs-CRP and with a cumulative score of risk factors. Conclusions: LBW children display altered EF that is related to early changes in CVD risk factors. The differences found in the metabolic parameters might indicate a pro-inflammatory state. This hypothesis is also supported by the laboratory findings and the correlation between EF and the number of CVD risk factors, suggesting that very early lifestyle interventions may be needed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Children
dc.subject
Endothelial Function
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Cardiovascular Risk Factor
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Low Birthweight
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Medicina Critica y de Emergencia
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Vascular Function in Children with Low Birthweight and Its Relationship with Early Markers of Cardiovascular Risk
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-28T13:57:24Z
dc.identifier.eissn
1663-2826
dc.journal.volume
85
dc.journal.number
6
dc.journal.pagination
396-405
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Joo Turoni, Claudio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Chaila, Zulema. Provincia de Tucumán. Ministerio de Salud. Hospital del Niño Jesús. Servicio de Endocrinología; Argentina
dc.description.fil
Fil: Chahla, Rossana. Provincia de Tucumán. Sistema Provincial de Salud. Instituto de Maternidad Nuestra Señora de Las Mercedes; Argentina
dc.description.fil
Fil: Bazan de Casella, María Cristina del Valle. Provincia de Tucumán. Ministerio de Salud. Hospital del Niño Jesús. Servicio de Endocrinología; Argentina
dc.description.fil
Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.journal.title
Hormone Research in Paediatrics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1159/000445949
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/445949
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