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dc.contributor.author
Holtzman, Jessica N
dc.contributor.author
Lolich, Maria
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dc.contributor.author
Ketter, Terence A
dc.contributor.author
Vázquez, Gustavo H
dc.date.available
2018-07-11T19:16:16Z
dc.date.issued
2015-04
dc.identifier.citation
Holtzman, Jessica N; Lolich, Maria; Ketter, Terence A; Vázquez, Gustavo H; Clinical characteristics of bipolar disorder: a comparative study between Argentina and the United States; Springer-v D I Verlag Gmbh; International Journal of Bipolar Disorders; 3; 1; 4-2015; 3-8
dc.identifier.issn
2194-7511
dc.identifier.uri
http://hdl.handle.net/11336/51771
dc.description.abstract
Background: Bipolar disorder presents with diverse clinical manifestations. Numerous investigators have sought to identify variables that may predict a more severe illness course. Methods: With the objective of studying the clinical characteristics of bipolar patients between South and North America, a comparison was performed between a sample from Argentina (n = 449) and a sample from the United States (n = 503) with respect to demographics and clinical characteristics, including presence of comorbidities. Results: The Argentinian sample had more unfavorable demographics and higher rates of prior psychiatric hospitalization and prior suicide attempt but a better social outcome. However, the sample from the United States had a higher rate of prior year rapid cycling, as well as younger bipolar disorder onset age (mean ± SD, 17.9 ± 8.4 vs. 27.1 ± 11.4 years) and more severe clinical morbidity, though there was no significant difference in terms of the total duration of the illness. Argentinian compared to American patients were taking more mood stabilizers and benzodiazepines/hypnotics, but fewer antipsychotics and other psychotropic medications, when considering patients in aggregate as well as when stratifying by illness subtype (bipolar I versus bipolar II) and by illness onset age (≤21 vs. >21 years). However, there was no significant difference in rate of antidepressant prescription between the two samples considered in aggregate. Conclusions: Although possessing similar illness durations, these samples presented significant clinical differences and distinctive prescription patterns. Thus, though the Argentinian compared to North American patients had more unfavorable demographics, they presented a better social outcome and, in several substantive ways, more favorable illness characteristics. In both samples, early onset (age ≤ 21 years) was a marker for poor prognosis throughout the illness course, although this phenomenon appeared more robust in North America. Keywords: Argentina; Bipolar disorder; Clinical characteristics; Comparative; Early onset; Onset age; Prescription patterns; United States
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer-v D I Verlag Gmbh
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Argentina
dc.subject
Bipolar Disorder
dc.subject
Clinical Characteristics
dc.subject
Comparative
dc.subject.classification
Medicina Critica y de Emergencia
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Clinical characteristics of bipolar disorder: a comparative study between Argentina and the United States
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-11T18:11:51Z
dc.journal.volume
3
dc.journal.number
1
dc.journal.pagination
3-8
dc.journal.pais
Alemania
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dc.journal.ciudad
Heidelberg
dc.description.fil
Fil: Holtzman, Jessica N. Universidad de Palermo; Argentina. Stanford University School of Medicine; Estados Unidos
dc.description.fil
Fil: Lolich, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Palermo; Argentina
dc.description.fil
Fil: Ketter, Terence A. Stanford University School of Medicine; Estados Unidos
dc.description.fil
Fil: Vázquez, Gustavo H. Universidad de Palermo; Argentina
dc.journal.title
International Journal of Bipolar Disorders
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1186/s40345-015-0027-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-015-0027-z
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