Artículo
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population
Trinks, Julieta
; Nishida, Nao; Hulaniuk, María Laura; Caputo, Mariela
; Tsuchiura, Takayo; Marciano, Sebastián; Haddad, Leila; Blejer, Jorgelina L.; Bartoli, Sonia; Ameigeiras, Beatriz; Frías, Silvia E.; Vistarini, Cecilia; Heinrich, Fabiana; Remondegui, Carlos; Ceballos, Susana; Echenique, Gustavo; Charre Samman, Miguel; D'Amico, Claudia; Rojas, Amalia; Martínez, Alfredo; Ridruejo, Ezequiel
; Fernandez, Roberto Julio; Burgos Pratx, Leandro; Salamone, Horacio J.; Nuñez, Felix A.; Galdame, Omar; Gadano, Adrián Carlos; Corach, Daniel
; Sugiyama, Masaya; Flichman, Diego Martin
; Tokunaga, Katsushi; Mizokami, Masashi
Fecha de publicación:
10/2017
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Liver International
ISSN:
1478-3223
e-ISSN:
1478-3231
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background & Aims: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown. Methods: a total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients. Results: Native American ancestry prevailed in the north-western region when compared with central Argentina (P<.0001). However, no differences were observed among the three groups of each region. The distribution of HBV genotypes revealed significant differences (P<.0001). Three SNPs (rs3077, rs9277542 and rs7453920) showed a significant association with protection against chronic HBV and viral clearance in both regions. The remaining SNP showed a significant association with susceptibility to chronic HBV. The frequency rates of rs3077-T, related to protection against chronic HBV and viral clearance, were lower in north-western Argentina when compared with central Argentina. The same uneven frequency rates were observed for SNP rs9277542. Conclusions: this is the first study addressing the associations between the HLA-DP and HLA-DQ loci and the protection against chronic HBV and viral clearance in a multiethnic South American population. The uneven distribution of HLA-DP and HLA-DQ supports the HBV epidemiological differences observed in these two regions of Argentina with dissimilar ancestry genetic background.
Palabras clave:
Hbv
,
Genotypes
,
Hla Genes
,
Native American
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Trinks, Julieta; Nishida, Nao; Hulaniuk, María Laura; Caputo, Mariela; Tsuchiura, Takayo; et al.; Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population; Wiley Blackwell Publishing, Inc; Liver International; 37; 10; 10-2017; 1476-1487
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