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dc.contributor.author
Chattah, Ana Karina
dc.contributor.author
Zhang, Rongchun
dc.contributor.author
Mroue, Kamal H.
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Pfund, Laura
dc.contributor.author
Longhi, Marcela Raquel
dc.contributor.author
Ramamoorthy, Ayyalusamy
dc.contributor.author
Garnero, Claudia
dc.date.available
2018-07-11T14:40:19Z
dc.date.issued
2015-03
dc.identifier.citation
Chattah, Ana Karina; Zhang, Rongchun; Mroue, Kamal H.; Pfund, Laura; Longhi, Marcela Raquel; et al.; Investigating Albendazole Desmotropes by Solid-State NMR Spectroscopy; American Chemical Society; Molecular Pharmaceutics; 12; 3; 3-2015; 731-741
dc.identifier.issn
1543-8384
dc.identifier.uri
http://hdl.handle.net/11336/51721
dc.description.abstract
Characterization of the molecular structure and physicochemical solid-state properties of the solid forms of pharmaceutical compounds is a key requirement for successful commercialization as potential active ingredients in drug products. These properties can ultimately have a critical effect on the solubility and bioavailability of the final drug product. Here, the desmotropy of Albendazole forms I and II was investigated at the atomic level. Ultrafast magic angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) spectroscopy, together with powder X-ray diffraction, thermal analysis, and Fourier transform infrared spectroscopy, were performed on polycrystalline samples of the two solids in order to fully characterize and distinguish the two forms. High-resolution one-dimensional 1H, 13C, and 15N together with two-dimensional 1H/1H single quantum-single quantum, 1H/1H single quantum-double quantum, and 1H/13C chemical shift correlation solid-state NMR experiments under MAS conditions were extensively used to decipher the intramolecular and intermolecular hydrogen bonding interactions present in both solid forms. These experiments enabled the unequivocal identification of the tautomers of each desmotrope. Our results also revealed that both solid forms may be described as dimeric structures, with different intermolecular hydrogen bonds connecting the tautomers in each dimer.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Albendazole
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Characterization
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Desmotropy
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Rfdr
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Solid-State Nmr
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Tautomerism
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Ultrafast Mas
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Investigating Albendazole Desmotropes by Solid-State NMR Spectroscopy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-04T14:38:22Z
dc.identifier.eissn
1543-8392
dc.journal.volume
12
dc.journal.number
3
dc.journal.pagination
731-741
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
dc.description.fil
Fil: Zhang, Rongchun. University of Michigan; Estados Unidos
dc.description.fil
Fil: Mroue, Kamal H.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Pfund, Laura. University of Michigan; Estados Unidos
dc.description.fil
Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Ramamoorthy, Ayyalusamy. University of Michigan; Estados Unidos
dc.description.fil
Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.journal.title
Molecular Pharmaceutics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/mp500539g
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/mp500539g
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