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Artículo

Evolutionary footprints reveal insights into plant microRNA biogenesis

Chorostecki, Uciel PabloIcon ; Moro, BelénIcon ; Rojas, Arantxa Maria LarisaIcon ; Debernardi, Juan ManuelIcon ; Schapire, Arnaldo LuisIcon ; Notredame, Cedric; Palatnik, Javier FernandoIcon
Fecha de publicación: 06/2017
Editorial: American Society of Plant Biologist
Revista: Plant Cell
ISSN: 1040-4651
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

MicroRNAs (miRNAs) are endogenous small RNAs that recognize target sequences by base complementarity and play a role in the regulation of target gene expression. They are processed from longer precursor molecules that harbor a fold-back structure. Plant miRNA precursors are quite variable in size and shape, and are recognized by the processing machinery in different ways. However, ancient miRNAs and their binding sites in target genes are conserved during evolution. Here, we designed a strategy to systematically analyze MIRNAs from different species generating a graphical representation of the conservation of the primary sequence and secondary structure. We found that plant MIRNAs have evolutionary footprints that go beyond the small RNA sequence itself, yet their location along the precursor depends on the specific MIRNA. We show that these conserved regions correspond to structural determinants recognized during the biogenesis of plant miRNAs. Furthermore, we found that the members of the miR166 family have unusual conservation patterns and demonstrated that the recognition of these precursors in vivo differs from other known miRNAs. Our results describe a link between the evolutionary conservation of plant MIRNAs and the mechanisms underlying the biogenesis of these small RNAs and show that the MIRNA pattern of conservation can be used to infer the mode of miRNA biogenesis.
Palabras clave: Micrornas , Evolucion , Precursores , Plantas
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/51533
DOI: https://dx.doi.org/10.1105/tpc.17.00272
URL: http://www.plantcell.org/content/29/6/1248
Colecciones
Articulos(IBR)
Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Citación
Chorostecki, Uciel Pablo; Moro, Belén; Rojas, Arantxa Maria Larisa; Debernardi, Juan Manuel; Schapire, Arnaldo Luis; et al.; Evolutionary footprints reveal insights into plant microRNA biogenesis; American Society of Plant Biologist; Plant Cell; 29; 6; 6-2017; 1248-1261
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