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dc.contributor.author
Obara, Isaiah
dc.contributor.author
Nielsen, Morten
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Jeschek, Marie
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Nijhof, Ard
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Mazzoni, Camila J.
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Svitek, Nicholas
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Steinaa, Lucilla
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Awino, Elias
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Olds, Cassandra
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Jabbar, Ahmed
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Clausen, Peter Henning
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Bishop, Richard P.
dc.date.available
2018-07-06T15:52:43Z
dc.date.issued
2016-05
dc.identifier.citation
Obara, Isaiah; Nielsen, Morten; Jeschek, Marie; Nijhof, Ard; Mazzoni, Camila J.; et al.; Sequence diversity between class I MHC loci of African native and introduced Bos taurus cattle in Theileria parva endemic regions: in silico peptide binding prediction identifies distinct functional clusters; Springer; Immunogenetics; 68; 5; 5-2016; 339-352
dc.identifier.issn
0093-7711
dc.identifier.uri
http://hdl.handle.net/11336/51498
dc.description.abstract
There is strong evidence that the immunity induced by live vaccination for control of the protozoan parasite Theileria parva is mediated by class I MHC-restricted CD8+ T cells directed against the schizont stage of the parasite that infects bovine lymphocytes. The functional competency of class I MHC genes is dependent on the presence of codons specifying certain critical amino acid residues that line the peptide binding groove. Compared with European Bos taurus in which class I MHC allelic polymorphisms have been examined extensively, published data on class I MHC transcripts in African taurines in T. parva endemic areas is very limited. We utilized the multiplexing capabilities of 454 pyrosequencing to make an initial assessment of class I MHC allelic diversity in a population of Ankole cattle. We also typed a population of exotic Holstein cattle from an African ranch for class I MHC and investigated the extent, if any, that their peptide-binding motifs overlapped with those of Ankole cattle. We report the identification of 18 novel allelic sequences in Ankole cattle and provide evidence of positive selection for sequence diversity, including in residues that predominantly interact with peptides. In silico functional analysis resulted in peptide binding specificities that were largely distinct between the two breeds. We also demonstrate that CD8+ T cells derived from Ankole cattle that are seropositive for T. parva do not recognize vaccine candidate antigens originally identified in Holstein and Boran (Bos indicus) cattle breeds.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ankole Cattle
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Cd8+ T Cell Epitopes
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Class I Mhc
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Pyrosequencing
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Theileria Parva
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Ingeniería Médica
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dc.subject.classification
Ingeniería Médica
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INGENIERÍAS Y TECNOLOGÍAS
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Otras Biotecnologías de la Salud
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Biotecnología de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Sequence diversity between class I MHC loci of African native and introduced Bos taurus cattle in Theileria parva endemic regions: in silico peptide binding prediction identifies distinct functional clusters
dc.type
info:eu-repo/semantics/article
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info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-19T16:52:40Z
dc.journal.volume
68
dc.journal.number
5
dc.journal.pagination
339-352
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Obara, Isaiah. Freie Universität Berlin; Alemania
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Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
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Fil: Jeschek, Marie. Berlin Center for Genomics in Biodiversity Research; Alemania
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Fil: Nijhof, Ard. Freie Universität Berlin; Alemania
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Fil: Mazzoni, Camila J.. Berlin Center for Genomics in Biodiversity Research; Alemania. Evolutionary Genetics; Alemania
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Fil: Svitek, Nicholas. International Livestock Research Institute; Kenia
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Fil: Steinaa, Lucilla. International Livestock Research Institute; Kenia
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Fil: Awino, Elias. International Livestock Research Institute; Kenia
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Fil: Olds, Cassandra. International Livestock Research Institute; Kenia
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Fil: Jabbar, Ahmed. Freie Universität Berlin; Alemania
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Fil: Clausen, Peter Henning. Freie Universität Berlin; Alemania
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Fil: Bishop, Richard P.. International Livestock Research Institute; Kenia
dc.journal.title
Immunogenetics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00251-016-0902-5
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info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00251-016-0902-5
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