Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Anxiety response and restraint-induced stress differentially affect ethanol intake in female adolescent rats

Acevedo, María BelénIcon ; Fabio, Maria CarolinaIcon ; Fernandez, Macarena SoledadIcon ; Pautassi, Ricardo MarcosIcon
Fecha de publicación: 10/2016
Editorial: Pergamon-Elsevier Science Ltd
Revista: Neuroscience
ISSN: 0306-4522
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

 Anxiety disorders are more likely to occur in women than in men, usually emerge during adolescence and exhibit high comorbidity with alcohol use disorders. Adolescents with high levels of anxiety or heightened reactivity to stress may be at-risk for developing alcohol use disorders. An approach to analyze if high l<span id="transmark" style="display: none; width: 0px; height: 0px;" />evels of inborn anxiety predict greater ethanol drinking is to assess the latter variable in subjects classified as high- or low- anxiety responders. The present study assessed ethanol drinking in adolescent, female Wistar, rats classified as high-, low- or average-anxiety responders and exposed or not to restraint stress (RS, Exp. 1). Classification was made through a multivariate index derived from testing anxiety responses in an elevated plus maze and a light-dark box tests. RS was applied after animals had been initiated to ethanol drinking. Intake of sweetened ethanol was unaffected by level of anxiety response. Adolescents with high levels of inborn anxiety exhibited significantly higher intake of unsweetened ethanol than counterparts with standard levels of anxiety, yet this effect was inhibited by RS exposure. Experiment 2 assessed FOS immunoreactivity after RS. Stress induced a significant increase in FOS immunoreactivity at the paraventricular nucleus, yet this effect was unaffected by level of anxiety response. Female adolescents with high levels of basal anxiety may be at-risk for exhibiting increased predisposition for ethanol intake and preference. The study also indicates that stress may exert differential effects on adolescent ethanol intake as a function of the level of anxiety response.  
Palabras clave: Adolescents , Ethanol Intake , Stress , Anxiety , Fos Inmunoreactivity
Ver el registro completo
 
Archivos asociados
Thumbnail
 
Tamaño: 1.517Mb
Formato: PDF
.
Descargar
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/51322
DOI: https://dx.doi.org/ 10.1016/j.neuroscience.2016.08.011
URL: https://www.sciencedirect.com/science/article/pii/S0306452216303748
Colecciones
Articulos(CIQUIBIC)
Articulos de CENTRO DE INVEST.EN QCA.BIOL.DE CORDOBA (P)
Citación
Acevedo, María Belén; Fabio, Maria Carolina; Fernandez, Macarena Soledad; Pautassi, Ricardo Marcos; Anxiety response and restraint-induced stress differentially affect ethanol intake in female adolescent rats; Pergamon-Elsevier Science Ltd; Neuroscience; 334; 10-2016; 259-274
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES