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dc.contributor.author
Rodriguez, Andrea Paola  
dc.contributor.author
Felice, Betiana  
dc.contributor.author
Sanchez, Maria Alejandra  
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Tsujigiwa, Hidetsugu  
dc.contributor.author
Felice, Carmelo Jose  
dc.contributor.author
Nagatsuka, Hitoshi  
dc.date.available
2018-07-04T20:44:18Z  
dc.date.issued
2016-06  
dc.identifier.citation
Rodriguez, Andrea Paola; Felice, Betiana; Sanchez, Maria Alejandra; Tsujigiwa, Hidetsugu; Felice, Carmelo Jose; et al.; In Vivo evaluation of adipogenic induction in fibrous and honeycomb-structured atelocollagen scaffolds; Elsevier Science; Materials Science and Engineering: C; 63; 6-2016; 125-130  
dc.identifier.issn
0928-4931  
dc.identifier.uri
http://hdl.handle.net/11336/51270  
dc.description.abstract
Nowadays, soft tissue restoration techniques are mainly focused on volume regeneration instead of function recovering. So far, autologous fat transplant has been the most popular method although its multiple reported problems like volume and function loss. Adipose tissue engineering therefore emerges as a solution for development of biological substitutes for soft tissue which promotes not only volume regeneration but also function restoration with minimal consequences. Here we tested fibrous-structured atelocollagen (FSA) scaffolds and honeycomb atelocollagen (HCA) scaffolds for their ability to induce adipogenesis in vivo. Implants were subjected to histological and immunohistochemical assessment after 1, 2, and 4 weeks of implantation. Our studies showed that FSA scaffolds induced in vivo a markedly adipogenic response, whereas an acute inflammatory process was observed at HCA scaffolds without tissue regeneration detected within them. Our histological findings concerning FSA scaffolds clearly showed the presence of adipose-like tissue surprisingly composed by a mixture of brown-like and white-like adipocytes at week 2 whereas only white-like adipocytes at week 4. Subsequent positive Pax7 immunostaining at weeks 1 and 2 suggested the existence of a common myogenic progenitor shared by brown-like and white-like adipocytes observed. Then, in this work we present FSA scaffolds as a promising structure for brown and white adipose tissue engineering.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Adipose Tissue Engineering  
dc.subject
Atelocollagen  
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In Vivo  
dc.subject
Myogenic Origin  
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White Adipocytes  
dc.subject.classification
Recubrimientos y Películas  
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Ingeniería de los Materiales  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
In Vivo evaluation of adipogenic induction in fibrous and honeycomb-structured atelocollagen scaffolds  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-28T13:57:52Z  
dc.journal.volume
63  
dc.journal.pagination
125-130  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Rodriguez, Andrea Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina. Okayama University; Japón  
dc.description.fil
Fil: Felice, Betiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina  
dc.description.fil
Fil: Sanchez, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina  
dc.description.fil
Fil: Tsujigiwa, Hidetsugu. Okayama University of Science; Japón  
dc.description.fil
Fil: Felice, Carmelo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina  
dc.description.fil
Fil: Nagatsuka, Hitoshi. Okayama University; Japón  
dc.journal.title
Materials Science and Engineering: C  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.msec.2016.02.055  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493116301485