Artículo
Fosfomycin residues in colostrum: Impact on morpho-physiology and microbiology of suckling piglets
Fernández Paggi, María Belén
; Martínez, Guadalupe
; Dieguez, Susana Nelly; Pérez, Denisa Soledad
; Decundo, Julieta María
; Riccio, Maria Belen
; Amanto, F. A.; Tapia, Maria Ofelia
; Soraci, Alejandro Luis
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Fecha de publicación:
06/2018
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Journal of Veterinary Pharmacology and Therapeutics
ISSN:
0140-7783
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Fosfomycin is a broad-spectrum bactericidal antibiotic widely used in pig farms for the treatment of a wide variety of bacterial infections. In this study, the elimination of disodium fosfomycin in colostrum/milk of the sow and the impact of this antibiotic on the microbiota and intestinal morpho-physiology of suckling piglets were analyzed. The average amount of fosfomycin eliminated in colostrum (after administration of 15 mg/kg IM) during the first 10 hr postpartum was 0.85 μg/ml, and the mean residual amount ingested by the piglets was 0.26 mg/kg. The elimination profile of fosfomycin concentrations in colostrum occurs at a time of profound changes in the morpho-physiology of the gastrointestinal tract of the piglet. However, the studied concentrations did not produce imbalances on the microbiota or on the morpho-physiology of the gastrointestinal tract of the piglet. Concentrations of fosfomycin were maintained in the mammary gland above the MIC for more than 8 hr for pathogenic bacteria of productive importance. This would indicate that fosfomycin may be considered safe for the specific treatment of bacterial infectious processes in sows during the peri- and postpartum period. This first study with disodium fosfomycin stimulates awareness in the proper use of antimicrobials at farrowing.
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Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Fernández Paggi, María Belén; Martínez, Guadalupe; Dieguez, Susana Nelly; Pérez, Denisa Soledad; Decundo, Julieta María; et al.; Fosfomycin residues in colostrum: Impact on morpho-physiology and microbiology of suckling piglets; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 41; 3; 6-2018; 415-427
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