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dc.contributor.author
Koehler, Niklas
dc.contributor.author
Stransky, Elke
dc.contributor.author
Shing, Mona
dc.contributor.author
Gaertner, Susanne
dc.contributor.author
Meyer, Mirjam
dc.contributor.author
Schreitmueller, Brigitte
dc.contributor.author
Leyhe, Thomas
dc.contributor.author
Laske, Cristoph
dc.contributor.author
Maetzler, Walter
dc.contributor.author
Kahle, Philipp
dc.contributor.author
Celej, Maria Soledad
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dc.contributor.author
Jovin, Thomas M.
dc.contributor.author
Fallgatter, Andreas
dc.contributor.author
Batra, Anil
dc.contributor.author
Buchkremer, Gherard
dc.contributor.author
Schott, Klauss
dc.contributor.author
Richartz-Salzburger, Elke
dc.date.available
2015-05-19T18:35:02Z
dc.date.issued
2013-05-31
dc.identifier.citation
Koehler, Niklas; Stransky, Elke; Shing, Mona; Gaertner, Susanne; Meyer, Mirjam; Schreitmueller, Brigitte; Leyhe, Thomas; Laske, Cristoph; Maetzler, Walter; Kahle, Philipp; Celej, Maria Soleda; Jovin, Thomas M.; Fallgatter, Andreas; Batra, Anil; Buchkremer, Gherard; Schott, Klauss; Richartz-Salzburger, Elke; Altered Serum IgG Levels to a-Synuclein in Dementia with Lewy Bodies and Alzheimer’s Disease.; Public Library Science; Plos One; 8; 5; 31-5-2013; 64649-64649;
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/509
dc.description.abstract
Natural self-reactive antibodies in the peripheral blood may play a considerable role in the control of potentially toxic proteins that may otherwise accumulate in the aging brain. The significance of serum antibodies reactive against asynuclein is not well known. We explored serum IgG levels to monomeric a-synuclein in dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) with a novel and validated highly sensitive ELISA assay. Antibody levels revealed stark differences in patients compared to healthy subjects and were dependent on diagnosis, disease duration and age. Anti-asynuclein IgG levels were increased in both patient groups, but in early DLB to a much greater extent than in AD. Increased antibody levels were most evident in younger patients, while with advanced age relatively low levels were observed, similar to healthy individuals, exhibiting stable antibody levels independent of age. Our data show the presence of differentially altered IgG levels against a-synuclein in DLB and AD, which may relate to a disturbed a-synuclein homeostasis triggered by the disease process. These observations may foster the development of novel, possibly preclinical biomarkers and immunotherapeutic strategies that target a-synuclein in neurodegenerative disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dementia with Lewy Bodies
dc.subject
Alzheimer
dc.subject
Synuclein
dc.subject.classification
Ciencias Naturales y Exactas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
Bioquímica y Biología Molecular (ídem 3.1.10)
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dc.title
Altered Serum IgG Levels to a-Synuclein in Dementia with Lewy Bodies and Alzheimer’s Disease.
dc.type
info:eu-repo/semantics/article
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dc.type
info:eu-repo/semantics/publishedVersion
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dc.type
info:ar-repo/semantics/artículo
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
8
dc.journal.number
5
dc.journal.pagination
64649-64649
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Koehler, Niklas. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Stransky, Elke. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Shing, Mona. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Gaertner, Susanne. Department of Psychiatry and Psychotherapy, EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Meyer, Mirjam. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Schreitmueller, Brigitte. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Leyhe, Thomas. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Laske, Cristoph. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Maetzler, Walter. Department of Neurodegeneration. HERTIE INSTITUTE FOR CLINICAL BRAIN RESEARCH;
dc.description.fil
Fil: Kahle, Philipp. FUNCTIONAL NEUROGENETICS. HERTIE INSTITUTE FOR CLINICAL;
dc.description.fil
Fil: Celej, Maria Soleda. MAX-PLANCK-INSTITUTE FOR BIOPHYSICAL CHEMISTRY; Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Centro de Invest.en Qca.biol.de Cordoba (p);
dc.description.fil
Fil: Jovin, Thomas M.. MAX-PLANCK-INSTITUTE FOR BIOPHYSICAL CHEMISTRY;
dc.description.fil
Fil: Fallgatter, Andreas. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Batra, Anil. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Buchkremer, Gherard. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Schott, Klauss. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.description.fil
Fil: Richartz-Salzburger, Elke. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;
dc.journal.title
Plos One
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0064649
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