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dc.contributor.author
Velazquez, Fabiola Noelia  
dc.contributor.author
Prucca, Cesar German  
dc.contributor.author
Etienne, Olivier  
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D'Astolfo, Diego S.  
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Silvestre, David C.  
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Boussin, Francois D.  
dc.contributor.author
Caputto, Beatriz Leonor  
dc.date.available
2018-07-02T14:13:22Z  
dc.date.issued
2015-07  
dc.identifier.citation
Velazquez, Fabiola Noelia; Prucca, Cesar German; Etienne, Olivier; D'Astolfo, Diego S.; Silvestre, David C.; et al.; Brain development is impaired in c-fos -/- mice; Impact Journals LLC; Oncotarget; 6; 19; 7-2015; 16883-16901  
dc.identifier.issn
1949-2553  
dc.identifier.uri
http://hdl.handle.net/11336/50818  
dc.description.abstract
c-Fos is a proto-oncogene involved in diverse cellular functions. Its deregulation has been associated to abnormal development and oncogenic progression. c-fos-/- mice are viable but present a reduction in their body weight and brain size. We examined the importance of c-Fos during neocortex development at 13.5, 14.5 and 16.5 days of gestation. At E14.5, neocortex thickness, apoptosis, mitosis and expression of markers along the different stages of Neural Stem Progenitor Cells (NSPCs) differentiation in c-fos-/- and wild-type mice were analyzed. A ~15% reduction in the neocortex thickness of c-fos-/- embryos was observed which correlates with a decrease in the number of differentiated cells and an increase in apoptosis at the ventricular zone. No difference in mitosis rate was observed, although the mitotic angle was predominantly vertical in c-fos-/- embryos, suggesting a reduced trend of NSPCs to differentiate. At E13.5, changes in differentiation markers start to be apparent and are still clearly observed at E16.5. A tendency of more AP-1/DNA complexes present in nuclear extracts of cerebral cortex from c-fos-/- embryos with no differences in the lipid synthesis activity was found. These results suggest that c-Fos is involved in the normal development of NSPCs by means of its AP-1 activity.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Impact Journals LLC  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Apoptosis  
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Differentiation  
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Neocortex  
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Neural Stem Progenitor Cells (Nspcs)  
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Neurogenesis  
dc.subject.classification
Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Brain development is impaired in c-fos -/- mice  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-29T16:43:57Z  
dc.journal.volume
6  
dc.journal.number
19  
dc.journal.pagination
16883-16901  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Velazquez, Fabiola Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina  
dc.description.fil
Fil: Prucca, Cesar German. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina  
dc.description.fil
Fil: Etienne, Olivier. Laboratoire de Radiopathologie, Cea, Irsm; Francia. Université Paris Diderot - Paris 7; Francia  
dc.description.fil
Fil: D'Astolfo, Diego S.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina  
dc.description.fil
Fil: Silvestre, David C.. Laboratoire de Radiopathologie, Cea, Irsm; Francia. Université Paris Diderot - Paris 7; Francia  
dc.description.fil
Fil: Boussin, Francois D.. Université Paris Diderot - Paris 7; Francia. Laboratoire de Radiopathologie, Cea, Irsm; Francia  
dc.description.fil
Fil: Caputto, Beatriz Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina  
dc.journal.title
Oncotarget  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/26143639  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.18632/oncotarget.4527