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dc.contributor.author
Rodeles Antonelli, Luz María
dc.contributor.author
Vicco, Miguel Hernán
dc.contributor.author
Bontempi, Iván
dc.contributor.author
Siano, Alvaro Sebastían
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Tonarelli, Georgina Guadalupe
dc.contributor.author
Bottasso, Oscar Adelmo
dc.contributor.author
Arias, Pablo
dc.contributor.author
Marcipar, Iván Sergio
dc.date.available
2018-06-29T19:32:39Z
dc.date.issued
2016-12
dc.identifier.citation
Rodeles Antonelli, Luz María; Vicco, Miguel Hernán; Bontempi, Iván; Siano, Alvaro Sebastían; Tonarelli, Georgina Guadalupe; et al.; Combined analysis of cross-reacting antibodies anti-β1AR and anti-B13 in advanced stages of Chagas heart disease; Wiley Blackwell Publishing, Inc; Tropical Medicine And International Health; 21; 12; 12-2016; 1545-1551
dc.identifier.issn
1360-2276
dc.identifier.uri
http://hdl.handle.net/11336/50789
dc.description.abstract
Objective: Autoantibodies cross-reacting with the β1 adrenergic receptor (anti-β1AR and anti-p2β) and cardiac myosin antigens (anti-B13) have been related to the pathogenesis of chronic Chagas heart disease (CCHD). Studies exploring their levels in different stages are scarce. We aimed to evaluate the relationship of these autoantibodies with the clinical profile of chronic patients, especially regarding their classificatory accuracy in severe presentation with heart failure. Methods and results: We conducted a cross-sectional study of 155 T. cruzi-seropositive patients and 26 age- and gender-matched healthy controls. They were categorised in three stages of CCHD. Serum antibodies were measured by specific immunoassays. Symptomatic individuals showed increased levels of anti-β1AR and anti-B13, while anti-p2β antibodies were similar between groups. A composite logistic regression model including anti-B13, anti-β1AR antibody levels and age was able to predict systolic heart failure yielding an area under the curve of 83% (sensitivity of 67% and specificity of 89%). Conclusions: In our study, anti-β1AR and anti-B13 antibodies were higher in individuals with chronic Chagas heart disease stage III, mainly in those with dilated cardiomyopathy associated with systolic heart failure. Logistic regression analysis showed that both antibodies were good predictors of severe CCHD. As well as being involved in disease progression, anti-β1AR and anti-B13 antibodies may be used as a serum marker of poor prognosis in terms of heart compromise.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Anti-B13 Antibodies
dc.subject
Beta-1 Adrenergic Receptors
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Chagas Disease
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Heart Failure
dc.subject.classification
Medicina Critica y de Emergencia
dc.subject.classification
Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Combined analysis of cross-reacting antibodies anti-β1AR and anti-B13 in advanced stages of Chagas heart disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-26T22:25:40Z
dc.journal.volume
21
dc.journal.number
12
dc.journal.pagination
1545-1551
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Rodeles Antonelli, Luz María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Vicco, Miguel Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Bontempi, Iván. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Siano, Alvaro Sebastían. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Tonarelli, Georgina Guadalupe. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Arias, Pablo. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Marcipar, Iván Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral; Argentina
dc.journal.title
Tropical Medicine And International Health
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/tmi.12791
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/tmi.12791


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