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dc.contributor.author
Fernández Hurst, Nicolás
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dc.contributor.author
Chanaday Ricagni, Natalí Luján
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dc.contributor.author
Roth, German Alfredo
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dc.date.available
2018-06-29T18:29:53Z
dc.date.issued
2015-10
dc.identifier.citation
Fernández Hurst, Nicolás; Chanaday Ricagni, Natalí Luján; Roth, German Alfredo; GABAergic agonists modulate the glutamate release from frontal cortex synaptosomes of rats with experimental autoimmune encephalomyelitis; Bentham Science; Inflamm Allergy Drug Targets.; 14; 2; 10-2015; 105-110
dc.identifier.issn
1871-5281
dc.identifier.uri
http://hdl.handle.net/11336/50744
dc.description.abstract
Experimental autoimmune encephalomyelitis (EAE) is a model that mimics many of the clinical and pathological features of multiple sclerosis. We have previously found a significant reduction in the GABAergic regulation of glutamate release from synaptosomes of EAE rats during the acute stage of the disease. In order to deepen into the possible metabolic pathways responsible for this alteration, in this work we evaluate the direct effect of different GABAergic agonists on the glutamate release and synapsin I phosphorylation in synaptosomes from the frontal cortex of control and EAE animals. The results show that all tested GABA agonists negatively modulate control synaptosomes, downregulating glutamate release and synapsin I phosphorylation on P-site 3, while synaptosomes from EAE group are less responsive to GABAergic agonists, with no change in their sensitivity to allosteric modulators. GABA and the GABA receptor agonists Muscimol (GABAA agonist) and Baclofen (GABAB agonist) caused a decrease in glutamate release paralleled by a similar reduction in synapsin I phosphorylation. In the case of the benzodiazepines Diazepam and Clonazepam (GABAA allosteric agonists) there was a higher effect on synapsin I phosphorylation than in glutamate release. These results indicate that the extent of GABAergic modulation of presynaptic terminals depends on the type of agonist employed and this regulation is altered in the frontal cortex during the acute phase of EAE.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Multiple Sclerosis
dc.subject
Gaba
dc.subject
Synaptosomes
dc.subject
Benzodiazepines
dc.title
GABAergic agonists modulate the glutamate release from frontal cortex synaptosomes of rats with experimental autoimmune encephalomyelitis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-29T16:44:26Z
dc.identifier.eissn
2212-4055
dc.journal.volume
14
dc.journal.number
2
dc.journal.pagination
105-110
dc.journal.pais
Emiratos Árabes Unidos
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dc.journal.ciudad
Dubai
dc.description.fil
Fil: Fernández Hurst, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
dc.description.fil
Fil: Chanaday Ricagni, Natalí Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
dc.description.fil
Fil: Roth, German Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
dc.journal.title
Inflamm Allergy Drug Targets.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/26631092
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/
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