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dc.contributor.author
Ghisoni, Karina
dc.contributor.author
Aguiar, Aderbal S.
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Oliveira, Paulo Alexandre de
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Matheus, Filipe Carvalho
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Gabach, Laura
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Perez, Mariela Fernanda
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Carlini, Valeria Paola
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Barbeito, Luis
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Mongeau, Raymond
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Lanfumey, Laurence
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Prediger, Rui Daniel
dc.contributor.author
Latini, Alexandra
dc.date.available
2018-06-29T17:20:45Z
dc.date.issued
2016-08
dc.identifier.citation
Ghisoni, Karina; Aguiar, Aderbal S.; Oliveira, Paulo Alexandre de; Matheus, Filipe Carvalho; Gabach, Laura; et al.; Neopterin acts as an endogenous cognitive enhancer; Academic Press Inc Elsevier Science; Brain Behavior And Immunity; 56; 8-2016; 156-164
dc.identifier.issn
0889-1591
dc.identifier.uri
http://hdl.handle.net/11336/50686
dc.description.abstract
Neopterin is found at increased levels in biological fluids from individuals with inflammatory disorders. The biological role of this pteridine remains undefined; however, due to its capacity to increase hemeoxygenase-1 content, it has been proposed as a protective agent during cellular stress. Therefore, we investigated the effects of neopterin on motor, emotional and memory functions. To address this question, neopterin (0.4 and/or 4 pmol) was injected intracerebroventricularly before or after the training sessions of step-down inhibitory avoidance and fear conditioning tasks, respectively. Memory-related behaviors were assessed in Swiss and C57BL/6 mice, as well as in Wistar rats. Moreover, the putative effects of neopterin on motor and anxiety-related parameters were addressed in the open field and elevated plus-maze tasks. The effects of neopterin on cognitive performance were also investigated after intraperitoneal lipopolysaccharide (LPS) administration (0.33 mg/kg) in interleukin-10 knockout mice (IL-10-/-). It was consistently observed across rodent species that neopterin facilitated aversive memory acquisition by increasing the latency to step-down in the inhibitory avoidance task. This effect was related to a reduced threshold to generate the hippocampal long-term potentiation (LTP) process, and reduced IL-6 brain levels after the LPS challenge. However, neopterin administration after acquisition did not alter the consolidation of fear memories, neither motor nor anxiety-related parameters. Altogether, neopterin facilitated cognitive processes, probably by inducing an antioxidant/anti-inflammatory state, and by facilitating LTP generation. To our knowledge, this is the first evidence showing the cognitive enhancer property of neopterin.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Learning And Memory
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Neopterin
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Neuroinflammation
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Neopterin acts as an endogenous cognitive enhancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-26T22:24:57Z
dc.journal.volume
56
dc.journal.pagination
156-164
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ghisoni, Karina. Universidade Federal de Santa Catarina; Brasil
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Fil: Aguiar, Aderbal S.. Universidade Federal de Santa Catarina; Brasil
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Fil: Oliveira, Paulo Alexandre de. Universidade Federal de Santa Catarina; Brasil
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Fil: Matheus, Filipe Carvalho. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Gabach, Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
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Fil: Perez, Mariela Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
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Fil: Barbeito, Luis. Instituto Pasteur de Montevideo; Uruguay
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Fil: Mongeau, Raymond. Université Paris Descartes. INSERM UMR. Centre de Psychiatrie et Neurosciences; Francia
dc.description.fil
Fil: Lanfumey, Laurence. Umr S894, Centre de Psychiatrie Et Neurosciences; Francia
dc.description.fil
Fil: Prediger, Rui Daniel. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Latini, Alexandra. Universidade Federal de Santa Catarina; Brasil
dc.journal.title
Brain Behavior And Immunity
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0889159116300393
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.bbi.2016.02.019


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  • Articulos(INICSA) [180]
    Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
  • Articulos(IFEC) [69]
    Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA

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