Mostrar el registro sencillo del ítem

dc.contributor.author Ghisoni, Karina
dc.contributor.author Aguiar, Aderbal S.
dc.contributor.author Oliveira, Paulo Alexandre de
dc.contributor.author Matheus, Filipe Carvalho
dc.contributor.author Gabach, Laura
dc.contributor.author Perez, Mariela Fernanda
dc.contributor.author Carlini, Valeria Paola
dc.contributor.author Barbeito, Luis
dc.contributor.author Mongeau, Raymond
dc.contributor.author Lanfumey, Laurence
dc.contributor.author Prediger, Rui Daniel
dc.contributor.author Latini, Alexandra
dc.date.available 2018-06-29T17:20:45Z
dc.date.issued 2016-08
dc.identifier.citation Ghisoni, Karina; Aguiar, Aderbal S.; Oliveira, Paulo Alexandre de; Matheus, Filipe Carvalho; Gabach, Laura; et al.; Neopterin acts as an endogenous cognitive enhancer; Academic Press Inc Elsevier Science; Brain Behavior And Immunity; 56; 8-2016; 156-164
dc.identifier.issn 0889-1591
dc.identifier.uri http://hdl.handle.net/11336/50686
dc.description.abstract Neopterin is found at increased levels in biological fluids from individuals with inflammatory disorders. The biological role of this pteridine remains undefined; however, due to its capacity to increase hemeoxygenase-1 content, it has been proposed as a protective agent during cellular stress. Therefore, we investigated the effects of neopterin on motor, emotional and memory functions. To address this question, neopterin (0.4 and/or 4 pmol) was injected intracerebroventricularly before or after the training sessions of step-down inhibitory avoidance and fear conditioning tasks, respectively. Memory-related behaviors were assessed in Swiss and C57BL/6 mice, as well as in Wistar rats. Moreover, the putative effects of neopterin on motor and anxiety-related parameters were addressed in the open field and elevated plus-maze tasks. The effects of neopterin on cognitive performance were also investigated after intraperitoneal lipopolysaccharide (LPS) administration (0.33 mg/kg) in interleukin-10 knockout mice (IL-10-/-). It was consistently observed across rodent species that neopterin facilitated aversive memory acquisition by increasing the latency to step-down in the inhibitory avoidance task. This effect was related to a reduced threshold to generate the hippocampal long-term potentiation (LTP) process, and reduced IL-6 brain levels after the LPS challenge. However, neopterin administration after acquisition did not alter the consolidation of fear memories, neither motor nor anxiety-related parameters. Altogether, neopterin facilitated cognitive processes, probably by inducing an antioxidant/anti-inflammatory state, and by facilitating LTP generation. To our knowledge, this is the first evidence showing the cognitive enhancer property of neopterin.
dc.format application/pdf
dc.language.iso eng
dc.publisher Academic Press Inc Elsevier Science
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject LEARNING AND MEMORY
dc.subject NEOPTERIN
dc.subject NEUROINFLAMMATION
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Neopterin acts as an endogenous cognitive enhancer
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-06-26T22:24:57Z
dc.journal.volume 56
dc.journal.pagination 156-164
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Ghisoni, Karina. Universidade Federal de Santa Catarina; Brasil
dc.description.fil Fil: Aguiar, Aderbal S.. Universidade Federal de Santa Catarina; Brasil
dc.description.fil Fil: Oliveira, Paulo Alexandre de. Universidade Federal de Santa Catarina; Brasil
dc.description.fil Fil: Matheus, Filipe Carvalho. Universidade Federal de Santa Catarina; Brasil
dc.description.fil Fil: Gabach, Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil Fil: Perez, Mariela Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
dc.description.fil Fil: Barbeito, Luis. Instituto Pasteur de Montevideo; Uruguay
dc.description.fil Fil: Mongeau, Raymond. Université Paris Descartes. INSERM UMR. Centre de Psychiatrie et Neurosciences; Francia
dc.description.fil Fil: Lanfumey, Laurence. Umr S894, Centre de Psychiatrie Et Neurosciences; Francia
dc.description.fil Fil: Prediger, Rui Daniel. Universidade Federal de Santa Catarina; Brasil
dc.description.fil Fil: Latini, Alexandra. Universidade Federal de Santa Catarina; Brasil
dc.journal.title Brain Behavior And Immunity
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0889159116300393
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.bbi.2016.02.019
dc.conicet.fuente individual


Archivos asociados

Aparece en la(s) siguiente(s) colección(ones)

  • Articulos(INICSA) [175]
    Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
  • Articulos(IFEC) [68]
    Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)