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dc.contributor.author
Tauber, Pablo E.
dc.contributor.author
Mansilla, Virginia
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Mercau Torres, Guillermo Adolfo
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Albano, Félix
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Corbalán, Ricardo R.
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Sanchez, Sara Serafina del V.
dc.contributor.author
Honore, Stella Maris
dc.date.available
2018-06-29T15:24:01Z
dc.date.issued
2016-05
dc.identifier.citation
Tauber, Pablo E.; Mansilla, Virginia; Mercau Torres, Guillermo Adolfo; Albano, Félix; Corbalán, Ricardo R.; et al.; Correlation between functional and ultrastructural substrate in Brugada syndrome; Elsevier; HeartRhythm Case Reports; 2; 3; 5-2016; 211-216
dc.identifier.issn
2214-0271
dc.identifier.uri
http://hdl.handle.net/11336/50632
dc.description.abstract
Brugada syndrome (BS) was reported for the first time in 1992 and is associated with an ST-segment elevation in the right precordial leads in the absence of any demonstrable structural heart disease, as well as with sudden cardiac death due to ventricular fibrillation (VF).1 A patent type 1 electrocardiogram (ECG) is diagnostic of BS and is characterized by a coved ST-segment elevation of ≥2 mm followed by a negative T wave in >1 right precordial lead (V1 to V3) in the presence or absence of a sodium channel–blocking agent, and in conjunction with 1 of the following: documented VF, polymorphic ventricular tachycardia (VT), a family history of sudden cardiac death at <45 years of age, coved-type ECGs in family members, inducibility of VT/VF with programmed electrical stimulation, syncope, or nocturnal agonal respiration.2 An autosomal dominant disease with incomplete penetrance, BS has been linked to mutations in SCN5A, the gene encoding the alpha subunit of the cardiac sodium channel. Still, SCN5A mutations have been reported in only approximately 20% of patients with BS diagnosed on the basis of clinical criteria, suggesting that other genetic defects or other disease mechanisms may give rise to this clinical picture.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Brugada Syndrome
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Heart Disease
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Ventricular Fibrillation
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Correlation between functional and ultrastructural substrate in Brugada syndrome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-28T13:56:13Z
dc.journal.volume
2
dc.journal.number
3
dc.journal.pagination
211-216
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Tauber, Pablo E.. Provincia de Tucumán. Sistema Provincial de Salud de Tucumán. Hospital Centro de Salud "Zenonj, Santillán"; Argentina
dc.description.fil
Fil: Mansilla, Virginia. Centro Modelo de Cardiología; Argentina
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Fil: Mercau Torres, Guillermo Adolfo. Centro Modelo de Cardiología; Argentina
dc.description.fil
Fil: Albano, Félix. Provincia de Tucumán. Sistema Provincial de Salud de Tucumán. Hospital Centro de Salud "Zenonj, Santillán"; Argentina
dc.description.fil
Fil: Corbalán, Ricardo R.. Centro Modelo de Cardiología; Argentina
dc.description.fil
Fil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Biología del Desarrollo | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Biología del Desarrollo; Argentina
dc.description.fil
Fil: Honore, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Biología del Desarrollo | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Departamento de Biología del Desarrollo; Argentina
dc.journal.title
HeartRhythm Case Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016%2Fj.hrcr.2015.12.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2214027115002699


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