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Artículo

Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow's Milk Proteins

Ibañez, Andres EstebanIcon ; Smaldini, Paola LorenaIcon ; Coria, Lorena; Delpino, María VictoriaIcon ; Pacífico, Lucila G.; Oliveira, Sergio C.; Risso, Gabriela SofíaIcon ; Pasquevich, Karina AlejandraIcon ; Fossati, Carlos AlbertoIcon ; Giambartolomei, Guillermo HernanIcon ; Docena, Guillermo H.Icon ; Cassataro, JulianaIcon
Fecha de publicación: 07/2013
Editorial: Public Library Science
Revista: Plos One
ISSN: 1932-6203
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that U-Omp16 from Brucella spp. delivered by the nasal route (i.n.) induced an inflammatory immune response in bronchoalveolar lavage (BAL) and lung tissues. Nasal co-administration of U-Omp16 with the model antigen (Ag) ovalbumin (OVA) increased the amount of Ag in lung tissues and induced OVA-specific systemic IgG and T helper (Th) 1 immune responses. The usefulness of U-Omp16 was also assessed in a mouse model of food allergy. U-Omp16 i.n. administration during sensitization ameliorated the hypersensitivity responses of sensitized mice upon oral exposure to Cow's Milk Protein (CMP), decreased clinical signs, reduced anti-CMP IgE serum antibodies and modulated the Th2 response in favor of Th1 immunity. Thus, U-Omp16 could be used as a broad Th1 mucosal adjuvant for different Ag formulations. © 2013 Ibañez et al.
Palabras clave: Adyuvant , Omp16 , Brucella , Vaccine
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/506
DOI: http://dx.doi.org/10.1371/journal.pone.0069438
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069438
Colecciones
Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Citación
Ibañez, Andres Esteban; Smaldini, Paola Lorena; Coria, Lorena; Delpino, María Victoria; Pacífico, Lucila G.; et al.; Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow's Milk Proteins; Public Library Science; Plos One; 8; 7; 7-2013; 1-13
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