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dc.contributor.author
Gonzalez, Lisandro Javier
dc.contributor.author
Bahr, Guillermo
dc.contributor.author
Vila, Alejandro Jose
dc.date.available
2018-06-29T14:05:20Z
dc.date.issued
2016-12
dc.identifier.citation
Gonzalez, Lisandro Javier; Bahr, Guillermo; Vila, Alejandro Jose; Lipidated β-lactamases: from bench to bedside; Future Medicine; Future Microbiology; 11; 12; 12-2016; 1495-1498
dc.identifier.issn
1746-0913
dc.identifier.uri
http://hdl.handle.net/11336/50584
dc.description.abstract
Carbapenemases represent one of the largest clinical threats to the action of carbapenems; the last resort drugs for the treatment of healthcare-associated infections caused by Gram-negative bacteria [1]. Metallo-β-lactamases (MBLs) are Zn(II)-dependent enzymes that constitute the largest family of carbapenemases of clinical impact. Among them, the New Delhi Metallo-β-lactamase (NDM-1) is a plasmid-encoded carbapenemase that has experienced the fastest and widest geographical spread, having been detected in more than 80 countries worldwide since its identification in 2008 [2]. Remarkably, the clinical success of this resistance determinant does not seem to be associated with the dissemination of a particular clone or genetic structure [3]. We have recently suggested that this particular success is due to the cellular localization of NDM-1: while all other known MBLs are soluble periplasmic proteins, NDM-1 is a lipoprotein anchored to the inner leaflet of the outer membrane in Gram-negative bacteria [4]. Despite NDM-1 being reported as a lipidated protein in 2011 [5], this fact was regarded as a biochemical curiosity and deserved little attention until recently when we reported that lipidation and membrane anchoring confer unique evolutionary advantages to NDM-1 [4].
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Future Medicine
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antibiotic Resistance
dc.subject
Lipoproteins
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Membrane-Anchoring
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Ndm-1
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Β-Lactamases
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Otras Ciencias Biológicas
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Lipidated β-lactamases: from bench to bedside
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-26T22:24:23Z
dc.journal.volume
11
dc.journal.number
12
dc.journal.pagination
1495-1498
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Gonzalez, Lisandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Bahr, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.journal.title
Future Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2217/fmb-2016-0176
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/fmb-2016-0176
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