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dc.contributor.author
Roy, Jeremy  
dc.contributor.author
Kim, Bongki  
dc.contributor.author
Hill, Eric  
dc.contributor.author
Visconti, Pablo  
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Krapf, Dario  
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Vinegoni, Claudio  
dc.contributor.author
Weissleder, Ralph  
dc.contributor.author
Brown, Dennis  
dc.contributor.author
Breton, Sylvie  
dc.date.available
2018-06-28T17:12:17Z  
dc.date.issued
2016-02  
dc.identifier.citation
Roy, Jeremy; Kim, Bongki; Hill, Eric; Visconti, Pablo; Krapf, Dario; et al.; Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging; Nature Publishing Group; Nature Communications; 7; 2-2016; 1-11; 10666  
dc.identifier.issn
2041-1723  
dc.identifier.uri
http://hdl.handle.net/11336/50382  
dc.description.abstract
Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach the lumen. Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostratified epithelia, we report here the surprising discovery that these basal cell projections-which we call axiopodia-periodically extend and retract over time. We found that axiopodia extensions and retractions follow an oscillatory pattern. This movement, which we refer to as periodic axial motility (PAM), is controlled by c-Src and MEK1/2-ERK1/2. Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projections. Such unexpected cell motility may reflect a novel mechanism by which specialized epithelial cells sample the luminal environment.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Nature Publishing Group  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
Src  
dc.subject
Pam  
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Principal Cells  
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Epididymis  
dc.subject.classification
Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-26T22:33:51Z  
dc.journal.volume
7  
dc.journal.pagination
1-11; 10666  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Roy, Jeremy. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos. AGADA Biosciences Inc.; Canadá  
dc.description.fil
Fil: Kim, Bongki. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos  
dc.description.fil
Fil: Hill, Eric. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos  
dc.description.fil
Fil: Visconti, Pablo. University of Massachussets; Estados Unidos  
dc.description.fil
Fil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. University of Massachussets; Estados Unidos  
dc.description.fil
Fil: Vinegoni, Claudio. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos  
dc.description.fil
Fil: Weissleder, Ralph. Harvard Medical School; Estados Unidos. Massachusetts General Hospital; Estados Unidos  
dc.description.fil
Fil: Brown, Dennis. Harvard Medical School; Estados Unidos. University of Massachussets; Estados Unidos. Massachusetts General Hospital; Estados Unidos  
dc.description.fil
Fil: Breton, Sylvie. Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados Unidos  
dc.journal.title
Nature Communications  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/ncomms10666  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncomms10666