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dc.contributor.author
Robledo, Diego
dc.contributor.author
Fernández, Carlos
dc.contributor.author
Hermida, Miguel
dc.contributor.author
Sciara, Andres Angel
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Álvarez Dios, José Antonio
dc.contributor.author
Cabaleiro, Santiago
dc.contributor.author
Caamaño, Rubén
dc.contributor.author
Martínez, Paulino
dc.contributor.author
Bouza, Carmen
dc.date.available
2018-06-28T17:03:33Z
dc.date.issued
2016-02
dc.identifier.citation
Robledo, Diego; Fernández, Carlos; Hermida, Miguel; Sciara, Andres Angel; Álvarez Dios, José Antonio; et al.; Integrative Transcriptome, Genome and Quantitative Trait Loci Resources Identify Single Nucleotide Polymorphisms in Candidate Genes for Growth Traits in Turbot
; MDPI; International Journal of Molecular Sciences; 17; 2; 2-2016; 1-17
dc.identifier.issn
1422-0067
dc.identifier.uri
http://hdl.handle.net/11336/50377
dc.description.abstract
Growth traits represent a main goal in aquaculture breeding programs and may be related to adaptive variation in wild fisheries. Integrating quantitative trait loci (QTL) mapping and next generation sequencing can greatly help to identify variation in candidate genes, which can result in marker-assisted selection and better genetic structure information. Turbot is a commercially important flatfish in Europe and China, with available genomic information on QTLs and genome mapping. Muscle and liver RNA-seq from 18 individuals was carried out to obtain gene sequences and markers functionally related to growth, resulting in a total of 20,447 genes and 85,344 single nucleotide polymorphisms (SNPs). Many growth-related genes and SNPs were identified and placed in the turbot genome and genetic map to explore their co-localization with growth-QTL markers. Forty-five SNPs on growth-related genes were selected based on QTL co-localization and relevant function for growth traits. Forty-three SNPs were technically feasible and validated in a wild Atlantic population, where 91% were polymorphic. The integration of functional and structural genomic resources in turbot provides a practical approach for QTL mining in this species. Validated SNPs represent a useful set of growth-related gene markers for future association, functional and population studies in this flatfish species.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Candidate Genes
dc.subject
Growth
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Integrative Genomics
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Rna-Seq
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Scophthalmusmaximus
dc.subject
Snp
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Turbot
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Integrative Transcriptome, Genome and Quantitative Trait Loci Resources Identify Single Nucleotide Polymorphisms in Candidate Genes for Growth Traits in Turbot
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-26T22:33:36Z
dc.journal.volume
17
dc.journal.number
2
dc.journal.pagination
1-17
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Robledo, Diego. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Fernández, Carlos. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Hermida, Miguel. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Sciara, Andres Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Álvarez Dios, José Antonio. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Cabaleiro, Santiago. Centro Tecnológico del Cluster de la Acuicultura de Galicia; España
dc.description.fil
Fil: Caamaño, Rubén. Centro Tecnológico del Cluster de la Acuicultura de Galicia; España
dc.description.fil
Fil: Martínez, Paulino. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Bouza, Carmen. Universidad de Santiago de Compostela; España
dc.journal.title
International Journal of Molecular Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms17020243
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1422-0067/17/2/243
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