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dc.contributor.author
Tabernero, Patricia  
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Mayxay, Mayfong  
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Culzoni, Maria Julia  
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Dwivedi, Prabha  
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Swamidoss, Isabel  
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Allan, Elizabeth Louise  
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Khanthavong, Maniphone  
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Phonlavong, Chindaphone  
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Vilayhong, Chantala  
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Yeuchaixiong, Sengchanh  
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Sichanh, Chanvilay  
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Sengaloundeth, Sivong  
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Kaur, Harparkash  
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Fernandez, Facundo M.  
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Green, Michael D.  
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Newton, Paul N.  
dc.date.available
2018-06-28T16:57:17Z  
dc.date.issued
2015-06  
dc.identifier.citation
Tabernero, Patricia; Mayxay, Mayfong; Culzoni, Maria Julia; Dwivedi, Prabha; Swamidoss, Isabel; et al.; A Repeat Random Survey of the Prevalence of Falsified and Substandard Antimalarials in the Lao PDR: A Change for the Better; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 92; 6; 6-2015; 95-104  
dc.identifier.issn
0002-9637  
dc.identifier.uri
http://hdl.handle.net/11336/50375  
dc.description.abstract
In 2003, a stratified random sample survey was conducted in the Lao People's Democratic Republic (Laos) to study the availability and quality of antimalarials in the private sector. In 2012, this survey was repeated to allow a statistically valid analysis of change through time. The counterfeit detection device 3 (CD-3) was used to assess packaging quality in the field and HPLC and mass spectroscopy analysis chemical analysis performed. The availability of oral artesunate monotherapies had significantly decreased from 22.9% (22) of 96 outlets in southern Laos in 2003 to 4.8% (7) of 144 outlets in 2012 (P < 0.0001). All the samples collected in the 2012 survey contained the correct active pharmaceutical ingredients (APIs) in contrast to the 21 (84%) falsified artesunate samples found in the 2003 survey. Although none of the medicines found in 2012 survey had evidence for falsification, 25.4% (37) of the samples were outside the 90-110% pharmacopeial limits of the label claim, suggesting that they were substandard or degraded. Results obtained from this survey show that patients are still exposed to poorly manufactured drugs or to ineffective medicines such as chloroquine. The quality of artemisinin-based combination therapies (ACTs) used in Laos needs to be monitored, since falsified ACTs would have devastating consequences in public health.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Society of Tropical Medicine and Hygiene  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Random Survey  
dc.subject
Antimalarials  
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Falsified And Substandard Medicines  
dc.subject.classification
Salud Ocupacional  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
A Repeat Random Survey of the Prevalence of Falsified and Substandard Antimalarials in the Lao PDR: A Change for the Better  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-04-27T20:27:04Z  
dc.identifier.eissn
1476-1645  
dc.journal.volume
92  
dc.journal.number
6  
dc.journal.pagination
95-104  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Stanford  
dc.description.fil
Fil: Tabernero, Patricia. Lao Oxford Mahosot Hospital; China  
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Fil: Mayxay, Mayfong. University of Oxford; Reino Unido  
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Fil: Culzoni, Maria Julia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina  
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Fil: Dwivedi, Prabha. University Of Heath Sciences; China  
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Fil: Swamidoss, Isabel. U.S. Centers for Disease Control and Prevention; Estados Unidos  
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Fil: Allan, Elizabeth Louise. Georgia Institute of Techology; Estados Unidos  
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Fil: Khanthavong, Maniphone. U.S. Centers for Disease Control and Prevention; Estados Unidos  
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Fil: Phonlavong, Chindaphone. U.S. Centers for Disease Control and Prevention; Estados Unidos  
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Fil: Vilayhong, Chantala. Centre of Malariology, Parasitology and Entomology; China  
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Fil: Yeuchaixiong, Sengchanh. Centre of Malariology, Parasitology and Entomology; China  
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Fil: Sichanh, Chanvilay. Bureau of Food and Drug Inspection; China  
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Fil: Sengaloundeth, Sivong. Food and Drug Department; China  
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Fil: Kaur, Harparkash. University of London; Reino Unido  
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Fil: Fernandez, Facundo M.. Georgia Institute of Techology; Estados Unidos  
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Fil: Green, Michael D.. National Center for Infectious Diseases; Estados Unidos  
dc.description.fil
Fil: Newton, Paul N.. University of Oxford; Reino Unido  
dc.journal.title
American Journal of Tropical Medicine and Hygiene  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4269/ajtmh.15-0057  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455074/  
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info:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.15-0057  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.4269%2Fajtmh.15-0057