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dc.contributor.author
Savtchouk, Iaroslav
dc.contributor.author
Sun, Lu
dc.contributor.author
Bender, Crhistian Luis
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dc.contributor.author
Lee, Hyang Burm
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Szabó, Gábor
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Gasparini, Sonia
dc.contributor.author
Liu, Siqiong June
dc.date.available
2018-06-28T15:11:25Z
dc.date.issued
2016-09
dc.identifier.citation
Savtchouk, Iaroslav; Sun, Lu; Bender, Crhistian Luis; Lee, Hyang Burm; Szabó, Gábor; et al.; Topological regulation of synaptic AMPA receptor expression by the RNA-Binding protein CPEB3; Elsevier B.V.; Cell Reports; 17; 1; 9-2016; 86-103
dc.identifier.issn
2211-1247
dc.identifier.uri
http://hdl.handle.net/11336/50350
dc.description.abstract
Synaptic receptors gate the neuronal response to incoming signals, but they are not homogeneously distributed on dendrites. A spatially defined receptor distribution can preferentially amplify certain synaptic inputs, resize receptive fields of neurons, and optimize information processing within a neuronal circuit. Thus, a longstanding question is how the spatial organization of synaptic receptors is achieved. Here, we find that action potentials provide local signals that influence the distribution of synaptic AMPA receptors along dendrites in mouse cerebellar stellate cells. Graded dendritic depolarizations elevate CPEB3 protein at proximal dendrites, where we suggest that CPEB3 binds to GluA2 mRNA, suppressing GluA2 protein synthesis leading to a distance-dependent increase in synaptic GluA2 AMPARs. The activity-induced expression of CPEB3 requires increased Ca2+ and PKC activation. Our results suggest a cell-autonomous mechanism where sustained postsynaptic firing drives graded local protein synthesis, thus directing the spatial organization of synaptic AMPARs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier B.V.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Action Potentials
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Ampa Receptor
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Calcium Imaging
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Cerebellar Stellate Cell
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Cpeb3
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Dendritic Gradient
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Glua2
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Pkc
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Subunit Composition
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Topostatic Plasticity
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Topological regulation of synaptic AMPA receptor expression by the RNA-Binding protein CPEB3
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-26T17:18:07Z
dc.identifier.eissn
2211-1247
dc.journal.volume
17
dc.journal.number
1
dc.journal.pagination
86-103
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Savtchouk, Iaroslav. University of Pennsylvania; Estados Unidos. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos
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Fil: Sun, Lu. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos. University of Pennsylvania; Estados Unidos
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Fil: Bender, Crhistian Luis. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
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Fil: Lee, Hyang Burm. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Szabó, Gábor. Institute Of Experimental Medicine Hungarian Academy Of Sciences; . LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos. Institute of Experimental Medicine. Laboratory of Molecular Biology and Genetics; Hungría
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Fil: Gasparini, Sonia. LSU Health Sciences Center. Neuroscience Center of Excellence; Estados Unidos. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos
dc.description.fil
Fil: Liu, Siqiong June. LSU Health Sciences Center. Department of Cell Biology and Anatomy; Estados Unidos. University of Pennsylvania; Estados Unidos
dc.journal.title
Cell Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.celrep.2016.08.094
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124716312037
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