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dc.contributor.author
Batista, Andrea N. L.
dc.contributor.author
Dos Santos Pinto, José Roberto A.
dc.contributor.author
Batista, Joao M.
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Souza Moreira, Tatiana M.
dc.contributor.author
Santoni, Mariana M.
dc.contributor.author
Zanelli, Cleslei F.
dc.contributor.author
Kato, Massuo J.
dc.contributor.author
López, Silvia Noelí
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dc.contributor.author
Palma, Mario S.
dc.contributor.author
Furlan, Maysa
dc.date.available
2018-06-28T13:56:04Z
dc.date.issued
2017-05
dc.identifier.citation
Batista, Andrea N. L.; Dos Santos Pinto, José Roberto A.; Batista, Joao M.; Souza Moreira, Tatiana M.; Santoni, Mariana M.; et al.; The Combined Use of Proteomics and Transcriptomics Reveals a Complex Secondary Metabolite Network in Peperomia obtusifolia; American Chemical Society; Journal of Natural Products; 80; 5; 5-2017; 1275-1286
dc.identifier.issn
0163-3864
dc.identifier.uri
http://hdl.handle.net/11336/50314
dc.description.abstract
Peperomia obtusifolia, an ornamental plant from the Piperaceae family, accumulates a series of secondary metabolites with interesting biological properties. From a biosynthesis standpoint, this species produces several benzopyrans derived from orsellinic acid, which is a polyketide typically found in fungi. Additionally, the chiral benzopyrans were reported as racemic and/or as diastereomeric mixtures, which raises questions about the level of enzymatic control in the cyclization step for the formation of the 3,4-dihydro-2H-pyran moiety. Therefore, this article describes the use of shotgun proteomic and transcriptome studies as well as phytochemical profiling for the characterization of the main biosynthesis pathways active in P. obtusifolia. This combined approach resulted in the identification of a series of proteins involved in its secondary metabolism, including tocopherol cyclase and prenyltransferases. The activity of these enzymes was supported by the phytochemical profiling performed in different organs of P. obtusifolia. However, the polyketide synthases possibly involved in the production of orsellinic acid could not be identified, suggesting that orsellinic acid may be produced by endophytes intimately associated with the plant.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Peperomia Obtusifolia
dc.subject
Proteomics
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Transcriptomics
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Biosynthesis
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The Combined Use of Proteomics and Transcriptomics Reveals a Complex Secondary Metabolite Network in Peperomia obtusifolia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-26T22:22:40Z
dc.journal.volume
80
dc.journal.number
5
dc.journal.pagination
1275-1286
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington
dc.description.fil
Fil: Batista, Andrea N. L.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Dos Santos Pinto, José Roberto A.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Batista, Joao M.. Universidade Federal do São Carlos; Brasil
dc.description.fil
Fil: Souza Moreira, Tatiana M.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Santoni, Mariana M.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Zanelli, Cleslei F.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Kato, Massuo J.. Universidade de Sao Paulo; Brasil
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Fil: López, Silvia Noelí. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
dc.description.fil
Fil: Palma, Mario S.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Furlan, Maysa. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.journal.title
Journal of Natural Products
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1021/acs.jnatprod.6b00827
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.jnatprod.6b00827
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