Artículo
Exogenous GM1 ganglioside increases accumbal BDNF levels in rats
Fecha de publicación:
02/2015
Editorial:
Elsevier Science
Revista:
Behavioural Brain Research
ISSN:
0166-4328
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Gangliosides are compounds that are abundant throughout the CNS, participating actively in neuroplasticity. We previously described that exogenous GM1 ganglioside pretreatment enhances the rewarding properties of cocaine, evidenced by a lower number of sessions and/or dosage necessary to induce conditioned place preference (CPP). Since GM1 pretreatment did not modify cocaine's pharmacokinetic parameters, we suspected that the increased rewarding effect found might be mediated by BDNF, a neurotrophic factor closely related to cocaine addiction. This study was performed to investigate the possibility that GM1 may induce changes in BDNF levels in the nucleus accumbens (NAc), a core structure in the brain's reward circuitry, of rats submitted to three conditioning sessions with cocaine (10. mg/kg, i.p.). The results demonstrate that GM1 administration, which showed no rewarding effect by itself in the CPP, induced a significant increase of BDNF protein levels in the NAc, which may account for the increased rewarding effect of cocaine shown in the CPP paradigm.
Palabras clave:
Bdnf
,
Cocaine
,
Gm1
,
Nucleus Accumbens
,
Reward
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IFEC)
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Citación
Valdomero, Analía; Perondi, María Cecilia; Orsingher, Otto Alberto; Cuadra, Gabriel R.; Exogenous GM1 ganglioside increases accumbal BDNF levels in rats; Elsevier Science; Behavioural Brain Research; 278; 2-2015; 303-306
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