Artículo
Mechanism of the Reaction of Peroxynitrite with Mn-Superoxide Dismutase: Nitration of Critical Tyrosine-34
Demicheli, Veronica; Moreno, Diego Martin
; Jara, Gabriel Ernesto
; Carballal, Sebastian; Quijano, Celia; Ferrer Sueta, Gerardo; Rios, Natalia; Estrin, Dario Ariel
; Marti, Marcelo Adrian
; Radi, Rafael
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Fecha de publicación:
11/2014
Editorial:
Elsevier Science Inc
Revista:
Free Radical Biology and Medicine
ISSN:
0891-5849
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Manganese superoxide dismutase (MnSOD) is an antioxidantenzyme that acts as a superoxide detoxifier. Superoxide can reactwith nitric oxide to lead peroxynitrite and this reaction, that takesplace at near diffusion limited rates, can compete with MnSOD forsuperoxide. One of the most important bio-markers forperoxynitrite formation in vivo is tyrosine nitration, a posttranslationalmodification that can alter both the structure andfunction of a protein.
Palabras clave:
Superoxide Dismutase
,
Nitration
,
Inactivation
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Identificadores
Colecciones
Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Articulos de INST.DE QUIMICA ROSARIO
Citación
Demicheli, Veronica; Moreno, Diego Martin; Jara, Gabriel Ernesto; Carballal, Sebastian; Quijano, Celia; et al.; Mechanism of the Reaction of Peroxynitrite with Mn-Superoxide Dismutase: Nitration of Critical Tyrosine-34; Elsevier Science Inc; Free Radical Biology and Medicine; 76; 11-2014; 138-139
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