Artículo

Mechanism of the Reaction of Peroxynitrite with Mn-Superoxide Dismutase: Nitration of Critical Tyrosine-34

Demicheli, Veronica; Moreno, Diego MartinIcon ; Jara, Gabriel ErnestoIcon ; Carballal, Sebastian; Quijano, Celia; Ferrer Sueta, Gerardo; Rios, Natalia; Estrin, Dario ArielIcon ; Marti, Marcelo AdrianIcon ; Radi, Rafael
Fecha de publicación: 11/2014
Editorial: Elsevier Science Inc
Revista: Free Radical Biology and Medicine
ISSN: 0891-5849
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Manganese superoxide dismutase (MnSOD) is an antioxidantenzyme that acts as a superoxide detoxifier. Superoxide can reactwith nitric oxide to lead peroxynitrite and this reaction, that takesplace at near diffusion limited rates, can compete with MnSOD forsuperoxide. One of the most important bio-markers forperoxynitrite formation in vivo is tyrosine nitration, a posttranslationalmodification that can alter both the structure andfunction of a protein.
Palabras clave: Superoxide Dismutase , Nitration , Inactivation
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/50278
DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.108
URL: https://www.sciencedirect.com/science/article/pii/S0891584914005693
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Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Citación
Demicheli, Veronica; Moreno, Diego Martin; Jara, Gabriel Ernesto; Carballal, Sebastian; Quijano, Celia; et al.; Mechanism of the Reaction of Peroxynitrite with Mn-Superoxide Dismutase: Nitration of Critical Tyrosine-34; Elsevier Science Inc; Free Radical Biology and Medicine; 76; 11-2014; 138-139
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