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dc.contributor.author
Gomez, Laura Constanza
dc.contributor.author
Sottile Fleury, Mayra Lis
dc.contributor.author
Guerrero Gimenez, Martin Eduardo
dc.contributor.author
Zoppino, Felipe Carlos Martin
dc.contributor.author
Redondo, Analia Lourdes
dc.contributor.author
Gago, Francisco E.
dc.contributor.author
Orozco, Javier I.
dc.contributor.author
Tello, Olga M.
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Roqué, María
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Nadin, Silvina Beatriz
dc.contributor.author
Marzese, Diego Matías
dc.contributor.author
Vargas Roig, Laura Maria
dc.date.available
2018-06-26T22:38:24Z
dc.date.issued
2017-07
dc.identifier.citation
Gomez, Laura Constanza; Sottile Fleury, Mayra Lis; Guerrero Gimenez, Martin Eduardo; Zoppino, Felipe Carlos Martin; Redondo, Analia Lourdes; et al.; TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer; B M J Publishing Group; Journal Of Clinical Pathology; 71; 1; 7-2017; 52-58
dc.identifier.issn
0021-9746
dc.identifier.uri
http://hdl.handle.net/11336/50206
dc.description.abstract
Aim: Accumulated evidence suggests that aberrant methylation of the TP73 gene and increased levels of ΔNp73 in primary tumours correlate with poor prognosis. However, little is known regarding the transcriptional and functional regulation of the TP73 gene in breast cancer. The aim of the present study was to determine the expression of the ΔNp73 isoform, its relationship with DNA methylation of TP73 and their clinical prognostic significance in breast cancer patients. Methods: TP73 gene methylation was studied in TCGA datasets and in 70 invasive ductal breast carcinomas (IDCs). The expression of p73 isoforms was evaluated by immunohistochemistry (IHC) and Western blot and correlated with clinicopathological variables and clinical outcome. Results: We observed that the methylation of diverse CpG islands of TP73 differed significantly between molecular subtypes. An inverse correlation was found between p73 protein expression and the methylation status of the TP73 gene. The expression of exon 3′ of p73 (only expressed in ΔNp73) was significantly higher in patients with wild-type p53. Immunohistochemical analysis revealed that all p73 isoforms were localised in both the nuclear and cytoplasmic compartments. We confirmed a positive association between the expression of ΔNp73 and high histological grade. Conclusions: Our findings suggest that high expression of ΔNp73 could be used to determine the aggressiveness of IDCs and could be incorporated in the pathologist's report.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
B M J Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Tp73
dc.subject
Breast Cancer
dc.subject
Methylation
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-18T19:11:08Z
dc.journal.volume
71
dc.journal.number
1
dc.journal.pagination
52-58
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Gomez, Laura Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Sottile Fleury, Mayra Lis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Guerrero Gimenez, Martin Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Zoppino, Felipe Carlos Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Redondo, Analia Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Gago, Francisco E.. Instituto Gineco-mamario; Argentina
dc.description.fil
Fil: Orozco, Javier I.. Ginecomamario Institute, Mendoza; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. John Wayne Cancer Institute at Providence Saint John’s Health Center; Estados Unidos
dc.description.fil
Fil: Tello, Olga M.. Ginecomamario Institute, Mendoza; Argentina
dc.description.fil
Fil: Roqué, María. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Nadin, Silvina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Marzese, Diego Matías. John Wayne Cancer Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Vargas Roig, Laura Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Journal Of Clinical Pathology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2017-204499
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1136/jclinpath-2017-204499
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