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Artículo

Sex- and age-associated differences in episodic-like memory and transcriptional regulation of hippocampal steroidogenic enzymes in rats

Rossetti, María FlorenciaIcon ; Varayoud, Jorgelina GuadalupeIcon ; Andreoli, Maria FlorenciaIcon ; Stoker, CoraIcon ; Luque, Enrique HugoIcon ; Ramos, Jorge GuillermoIcon
Fecha de publicación: 07/2018
Editorial: Elsevier Ireland
Revista: Molecular and Cellular Endocrinology
ISSN: 0303-7207
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

The aim of this study was to evaluate the episodic-like memory (ELM) and the transcriptional regulation of the enzymes involved in hippocampal allopregnanolone synthesis in young adult and middle-aged male and female rats. Young adult males, but not middle-aged ones, showed a good performance in the ELM task. In contrast, neither young nor middle-aged females were able to discriminate the spatial order in which the objects were presented. In females, aging decreased the transcription of steroidogenic-related genes. In addition, the mRNA levels of 5α-reductase-1 were higher and the methylation of its promoter was lower in young adult females than in males, suggesting an epigenetic control. Further studies are needed to establish correlations between ELM and the transcriptional regulation of hippocampal steroidogenic enzymes. Our results contribute to the knowledge of sex differences in gene expression, methylation and memory during aging.
Palabras clave: Aging , Dna Methylation , Hippocampus , Neurosteroidogenic Enzymes , Sex
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/50152
DOI: http://dx.doi.org/10.1016/j.mce.2017.11.001
URL: https://www.sciencedirect.com/science/article/pii/S030372071730566X
Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos(ISAL)
Articulos de INSTITUTO DE SALUD Y AMBIENTE DEL LITORAL
Citación
Rossetti, María Florencia; Varayoud, Jorgelina Guadalupe; Andreoli, Maria Florencia; Stoker, Cora; Luque, Enrique Hugo; et al.; Sex- and age-associated differences in episodic-like memory and transcriptional regulation of hippocampal steroidogenic enzymes in rats; Elsevier Ireland; Molecular and Cellular Endocrinology; 470; 7-2018; 208-218
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