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Artículo

Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model

Katunar, Maria RosaIcon ; Gomez Sanchez, Andrea ValeriaIcon ; Ballarre, JosefinaIcon ; Baca, Matías; Vottola, Carlos; Orellano, Juan C.; Schell, Hanna; Duffo, Gustavo SergioIcon ; Cere, SilviaIcon
Fecha de publicación: 11/06/2014
Editorial: Springer
Revista: Progress in Biomaterials
ISSN: 2194-0517
Idioma: Español
Tipo de recurso: Artículo publicado
Clasificación temática:
Físico-Química, Ciencia de los Polímeros, Electroquímica; Biomateriales

Resumen

Mechanical properties and good biocompatibility of zirconium and some of its alloys focus these materials as good candidates for biomedical applications. The attractive in vivo performance of zirconium is mainly due to the presence of a protective oxide layer. In this preliminary study, surface modification of pure zirconium was made by anodisation in acidic media at low potentials, enhancing the barrier protection given by the oxides and the osseointegration. Electrochemical and SEM (scanning electron microscopy) assays were done in commercially pure zirconium cylinders and two surface conditions were compared: pure and zirconium anodised at 30V. The in vivo assays were held in a tibia rat model. The histological features and fluorochrome labelling changes of newly bone formed around implants were evaluated on the non-decalcified sections 63 days after surgery. Electrochemical and SEM assays showed that anodisation treatment would increased the barrier effect over the material and the in vivo assays showed a continuous newly bone formation around the implant with a different amount of osteocytes in their lacunaes depending the region. There was no significant change in bone thickness around both kinds of implants but conversely a significant increase in the mineralization apposition rate was determined for the anodised condition suggesting that anodisation treatment would stimulate and assist to the osseointegration process. We conclude that anodisation treatment at 30 V can stimulate the implant fixation in a rat model and this study would propose the study of zirconium as candidate material for permanent implant.
Palabras clave: Bone , Fluorochoromes , Zr Implant , Osseointegration , Orthopaedic Implant , Zirconium , Anodisation , In Vivo Model
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/5015
DOI: http://dx.doi.org/ 10.1007/s40204-014-0024-9
DOI: http://dx.doi.org/10.1007/s40204-014-0024-9
URL: http://link.springer.com/article/10.1007%2Fs40204-014-0024-9
Colecciones
Articulos(CCT - MAR DEL PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - MAR DEL PLATA
Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Katunar, Maria Rosa; Gomez Sanchez, Andrea Valeria; Ballarre, Josefina; Baca, Matías; Vottola, Carlos; et al.; Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model; Springer; Progress in Biomaterials; 3; 24; 11-6-2014; 1-10
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