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dc.contributor.author
Pescaretti, María de Las Mercedes
dc.contributor.author
Farizano, Juan Vicente
dc.contributor.author
Morero, Roberto Dionisio
dc.contributor.author
Delgado, Monica Alejandra
dc.date.available
2015-05-19T13:26:58Z
dc.date.issued
2013-09-04
dc.identifier.citation
María de Las Mercedes Pescaretti; Juan V. Farizano; Roberto Morero; Mónica A. Delgado; A novel insight on signal transduction mechanism of RcsCDB system in Salmonella enterica serovar Typhimurium; Public Library Science; Plos One; 8; 9; 2013-9; 1-10;
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/500
dc.description.abstract
The RcsCDB system of Salmonella enterica serovar Typhimurium is implicated in the control of capsule and flagella synthesis. The hybrid sensor RcsC, the phosphotransferase RcsD and the regulator RcsB, constitute the main components of the RcsCDB system. The proposed Rcs signaling cascade involves the autophosphorylation of RcsC and the transfer of the phosphate group to RcsB, mediated by RcsD. We previously reported that the overexpression of rcsB repress the transcription of rcsD by an autoregulation mechanism. Moreover, we demonstrated that during the rcsD repression, the RcsB-dependent flagella modulation remained active. These results suggest that the Rcs phosphorelay mechanism occurs even in the absence of RcsD. In this work, we established the existence of two alternative phosphorelay pathways driving activation of this system. We demonstrated that RcsC and RcsD can act as histidine kinase proteins which, after autophosphorylate, are able to independently transfer the phosphate to RcsB. Our results suggest that these pathways could be activated by different environmental signals, leading different levels of RcsB-phosphorylated to produce a differential gene modulation. These findings contribute to a better understanding of the complexity and importance of the Rcs system activation, where more than one phosphate flow pathway increases the possibilities to exert gene regulation for a quick environmental changes response.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Salmonella
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Rcscdb
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Mechanism
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Transduction
dc.subject.classification
Ciencias Naturales y Exactas
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Ciencias Biológicas
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Biología Celular, Microbiología
dc.title
A Novel Insight on Signal Transduction Mechanism of RcsCDB System in Salmonella enterica Serovar Typhimurium
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
8
dc.journal.number
9
dc.journal.pagination
1-10
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: María de Las Mercedes Pescaretti. CONSEJO NAC.DE INVEST.CIENTIF.Y TECNICAS. CTRO.CIENTIFICO TECNOL.CONICET - TUCUMAN. INST.SUP.DE INVEST.BIOLOGICAS.
dc.description.fil
Fil: Juan V. Farizano. CONSEJO NAC.DE INVEST.CIENTIF.Y TECNICAS. CTRO.CIENTIFICO TECNOL.CONICET - TUCUMAN. INST.SUP.DE INVEST.BIOLOGICAS.
dc.description.fil
Fil: Roberto Morero. CONSEJO NAC.DE INVEST.CIENTIF.Y TECNICAS. CTRO.CIENTIFICO TECNOL.CONICET - TUCUMAN. INST.SUP.DE INVEST.BIOLOGICAS.
dc.description.fil
Fil: Mónica A. Delgado. CONSEJO NAC.DE INVEST.CIENTIF.Y TECNICAS. CTRO.CIENTIFICO TECNOL.CONICET - TUCUMAN. INST.SUP.DE INVEST.BIOLOGICAS.
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0072527


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