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Artículo

Nanotoxicological and teratogenic effects: A linkage between dendrimer surface charge and zebrafish developmental stages

Calienni, Maria NataliaIcon ; Feas, Daniela AgustinaIcon ; Igartúa, DanielaIcon ; Chiaramoni, Nadia SilviaIcon ; Alonso, Silvia del ValleIcon ; Prieto, Maria JimenaIcon
Fecha de publicación: 12/2017
Editorial: Academic Press Inc Elsevier Science
Revista: Toxicology and Applied Pharmacology
ISSN: 0041-008X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Nano-materiales

Resumen

This article reports novel results about nanotoxicological and teratogenic effects of the PAMAM dendrimers DG4 and DG4.5 in zebrafish (Danio rerio). Zebrafish embryos and larvae were used as a rapid, high-throughput, cost-effective whole-animal model. The objective was to provide a more comprehensive and predictive developmental toxicity screening of DG4 and DG4.5 and test the influence of their surface charge. Nanotoxicological and teratogenic effects were assessed at developmental, morphological, cardiac, neurological and hepatic level. The effect of surface charge was determined in both larvae and embryos. DG4 with positive surface charge was more toxic than DG4.5 with negative surface charge. DG4 and DG4.5 induced teratogenic effects in larvae, whereas DG4 also induced lethal effects in both zebrafish embryos and larvae. However, larvae were less sensitive than embryos to the lethal effects of DG4. The platform of assays proposed and data obtained may contribute to the characterization of hazards and differential effects of these nanoparticles.
Palabras clave: Dendrimer , Developmental Toxicity , Nanotoxicology , Zebrafish
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/49866
URL: https://www.sciencedirect.com/science/article/pii/S0041008X17304040
DOI: https://doi.org/10.1016/j.taap.2017.10.003
Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Calienni, Maria Natalia; Feas, Daniela Agustina; Igartúa, Daniela; Chiaramoni, Nadia Silvia; Alonso, Silvia del Valle; et al.; Nanotoxicological and teratogenic effects: A linkage between dendrimer surface charge and zebrafish developmental stages; Academic Press Inc Elsevier Science; Toxicology and Applied Pharmacology; 337; 12-2017; 1-11
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