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dc.contributor.author
Carr, Robert
dc.contributor.author
Ozdag, Hilal
dc.contributor.author
Tekin, Nilgun
dc.contributor.author
Morris, Timothy
dc.contributor.author
Conget, Paulette
dc.contributor.author
Bruna, Flavia Alejandra
dc.contributor.author
Timar, Botond
dc.contributor.author
Gagyi, Eva
dc.contributor.author
Basak, Ranjan
dc.contributor.author
Naik, Omkar
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Auewarakul, Chirayu
dc.contributor.author
Srithana, Narongrit
dc.contributor.author
Dimamay, Mark Pierre
dc.contributor.author
Natividad, Filipinas
dc.contributor.author
Chung, June-Key
dc.contributor.author
Belder, Nevin
dc.contributor.author
Kuzu, Isinsu
dc.contributor.author
Omidvar, Nader
dc.contributor.author
Paez, Diana
dc.contributor.author
Padua, Rose Ann
dc.date.available
2018-06-22T21:08:26Z
dc.date.issued
2017-05
dc.identifier.citation
Carr, Robert; Ozdag, Hilal; Tekin, Nilgun; Morris, Timothy; Conget, Paulette; et al.; The effect of biological heterogeneity on R-CHOP treatment outcome in diffuse large B-cell lymphoma across five international regions; Taylor & Francis Ltd; Leukemia and Lymphoma; 58; 5; 5-2017; 1178-1183
dc.identifier.issn
1042-8194
dc.identifier.uri
http://hdl.handle.net/11336/49808
dc.description.abstract
Addressing the global burden of cancer, understanding its diverse biology, and promoting appropriate prevention and treatment strategies around the world has become a priority for the United Nations and International Atomic Energy Agency (IAEA), the WHO, and International Agency for Research on Cancer (IARC). The IAEA sponsored an international prospective cohort study to better understand biology, treatment response, and outcomes of diffuse large B-cell lymphoma (DLBCL) in low and middle-income countries across five UN-defined geographical regions. We report an analysis of biological variation in DLBCL across seven ethnic and environmentally diverse populations. In this cohort of 136 patients treated to a common protocol, we demonstrate significant biological differences between countries, characterized by a validated prognostic gene expression score (p <.0001), but International Prognostic Index (IPI)-adjusted survivals in all participating countries were similar. We conclude that DLBCL treatment outcomes in these populations can be benchmarked to international standards, despite biological heterogeneity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dlbcl
dc.subject
Gene Expression
dc.subject
Prognosis
dc.subject
Risk Stratification
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The effect of biological heterogeneity on R-CHOP treatment outcome in diffuse large B-cell lymphoma across five international regions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-18T19:10:34Z
dc.journal.volume
58
dc.journal.number
5
dc.journal.pagination
1178-1183
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Carr, Robert. King's College; Reino Unido
dc.description.fil
Fil: Ozdag, Hilal. Ankara University; Turquía
dc.description.fil
Fil: Tekin, Nilgun. Ankara University; Turquía
dc.description.fil
Fil: Morris, Timothy. Colegio Universitario de Londres; Reino Unido
dc.description.fil
Fil: Conget, Paulette. Universidad del Desarrollo; Chile
dc.description.fil
Fil: Bruna, Flavia Alejandra. Universidad del Desarrollo; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
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Fil: Timar, Botond. Semmelweis Egyetem; Hungría
dc.description.fil
Fil: Gagyi, Eva. Semmelweis University; Hungría
dc.description.fil
Fil: Basak, Ranjan. Tata Memorial Hospital; India
dc.description.fil
Fil: Naik, Omkar. Tata Memorial Hospital; India
dc.description.fil
Fil: Auewarakul, Chirayu. Siriraj Hospital; Tailandia
dc.description.fil
Fil: Srithana, Narongrit. Siriraj Hospital; Tailandia
dc.description.fil
Fil: Dimamay, Mark Pierre. St Luke’s Medical Centre Manila; Filipinas
dc.description.fil
Fil: Natividad, Filipinas. St Luke’s Medical Centre Manila; Filipinas
dc.description.fil
Fil: Chung, June-Key. Seoul National University Hospital; Corea del Sur
dc.description.fil
Fil: Belder, Nevin. Ankara University; Turquía
dc.description.fil
Fil: Kuzu, Isinsu. Ankara University; Turquía
dc.description.fil
Fil: Omidvar, Nader. Cardiff University; Reino Unido
dc.description.fil
Fil: Paez, Diana. International Atomic Energy Agency; Austria
dc.description.fil
Fil: Padua, Rose Ann. Université Paris Diderot - Paris 7; Francia
dc.journal.title
Leukemia and Lymphoma
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/10428194.2016.1231308
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10428194.2016.1231308
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