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dc.contributor.author
Egan, Benova T.
dc.contributor.author
Szeiffova, Bacova B.
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Viczenczova, C
dc.contributor.author
Diez, Emiliano Raúl
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Barancik, M.
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Tribulova, N.
dc.date.available
2018-06-22T20:56:32Z
dc.date.issued
2016-09
dc.identifier.citation
Egan, Benova T.; Szeiffova, Bacova B.; Viczenczova, C; Diez, Emiliano Raúl; Barancik, M.; et al.; Protection of cardiac cell-to-cell coupling attenuate myocardial remodeling and proarrhythmia induced by hypertension; Acad Sciences Czech Republic; Physiological Research; 65; Suppl. 1; 9-2016; 29-42
dc.identifier.issn
0862-8408
dc.identifier.uri
http://hdl.handle.net/11336/49802
dc.description.abstract
Gap junction connexin channels are important determinants of myocardial conduction and synchronization that is crucial for coordinated heart function. One of the main risk factors for cardiovascular events that results in heart attack, congestive heart failure, stroke as well as sudden arrhythmic death is hypertension. Mislocalization and/or dysfunction of specific connexin-43 channels due to hypertension-induced myocardial remodeling have been implicated in the occurrence of lifethreatening arrhythmias and heart failure in both, humans as well as experimental animals. Recent studies suggest that downregulation of myocardial connexin-43, its abnormal distribution and/or phosphorylation might be implicated in this process. On the other hand, treatment of hypertensive animals with cardioprotective drugs (e.g. statins) or supplementation with non-pharmacological compounds, such as melatonin, omega-3 fatty acids and red palm oil protects from lethal arrhythmias. The antiarrhythmic effects are attributed to the attenuation of myocardial connexin-43 abnormalities associated with preservation of myocardial architecture and improvement of cardiac conduction. Findings uncover novel mechanisms of cardioprotective (antihypertensive and antiarrhythmic) effects of compounds that are used in clinical settings. Well-designed trials are needed to explore the antiarrhythmic potential of these compounds in patients suffering from hypertension.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Acad Sciences Czech Republic
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Hypertension
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Arrhythmias
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Connexin-43
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Cardioprotection
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Protection of cardiac cell-to-cell coupling attenuate myocardial remodeling and proarrhythmia induced by hypertension
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-18T19:10:25Z
dc.journal.volume
65
dc.journal.number
Suppl. 1
dc.journal.pagination
29-42
dc.journal.pais
República Checa
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Praga
dc.description.fil
Fil: Egan, Benova T.. Institute For Heart Research; Eslovaquia
dc.description.fil
Fil: Szeiffova, Bacova B.. Institute For Heart Research; Eslovaquia
dc.description.fil
Fil: Viczenczova, C. Institute For Heart Research,; Eslovaquia
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Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Cs.médicas. Cátedra de Fisiología Humana Normal; Argentina
dc.description.fil
Fil: Barancik, M.. Institute For Heart Research,; Eslovaquia
dc.description.fil
Fil: Tribulova, N.. Institute For Heart Research,; Eslovaquia
dc.journal.title
Physiological Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.biomed.cas.cz/physiolres/pdf/65%20Suppl%201/65_S29.pdf
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