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Artículo

Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage

Pochettino, Arístides AngelIcon ; Hapon, María BelénIcon ; Biolatto, Silvana Micaela; Madariaga, María José; Jahn, Graciela AlmaIcon ; Konjuh, Cintia NadinaIcon
Fecha de publicación: 10/2016
Editorial: Taylor & Francis
Revista: Drug And Chemical Toxicology
ISSN: 0148-0545
e-ISSN: 1525-6014
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Toxicología

Resumen

The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is used on a wide variety of terrestrial and aquatic broadleaf weeds. 2,4-D has been shown to produce a wide range of adverse effects on animal and human health. The aim of the current study was to evaluate the effects of pre- and postnatal exposure to 2,4-D on rat ventral prostate (VP). Pregnant rats were exposed daily to oral doses of 70 mg/kg/day of 2,4-D from 16 days of gestation up to 23 days after delivery. Then, the treated groups (n = 8) were fed with a 2,4-D added diet until sacrificed by decapitation on postnatal day (PND) 45, 60, or 90. Morphometric studies were performed and androgen receptor (AR) protein levels in the VP were determined. AR, insulin-like growth factor-I (IGF-1) and insulin-like growth factor-I receptor (IGF-1R) mRNA expression in the VP along with testosterone (T), dihydroxytestosterone (DHT), growth hormone (GH) and IGF-1 serum levels were also determined to ascertain whether these parameters were differentially affected. Results of this study showed that 2,4-D exposure during gestation and until adulthood altered development of the prostate gland in male rats, delaying it at early ages while increasing its size in adults, indicate that 2,4-D could behave as endocrine disruptors (EDs).
Palabras clave: 2,4-Dichlorophenoxyacetic Herbicide , Androgen Receptor , Developmental Toxicity , Hormone
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/49760
DOI: http://dx.doi.org/10.3109/01480545.2015.1130718
URL: https://www.tandfonline.com/doi/abs/10.3109/01480545.2015.1130718
Colecciones
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Pochettino, Arístides Angel; Hapon, María Belén; Biolatto, Silvana Micaela; Madariaga, María José; Jahn, Graciela Alma; et al.; Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage; Taylor & Francis; Drug And Chemical Toxicology; 39; 4; 10-2016; 392-399
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