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dc.contributor.author
Riquelme, Sebastián A.
dc.contributor.author
Carreño, Leandro J.
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Espinoza, Janyra A.
dc.contributor.author
Mackern Oberti, Juan Pablo
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Alvarez Lobos, Manuel M.
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Riedel, Claudia
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Bueno, Susan M.
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Kalergis, Alexis M.
dc.date.available
2018-06-22T19:40:58Z
dc.date.issued
2016-09
dc.identifier.citation
Riquelme, Sebastián A.; Carreño, Leandro J.; Espinoza, Janyra A.; Mackern Oberti, Juan Pablo; Alvarez Lobos, Manuel M.; et al.; Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance; Wiley Blackwell Publishing, Inc; Immunology; 149; 1; 9-2016; 1-12
dc.identifier.issn
0019-2805
dc.identifier.uri
http://hdl.handle.net/11336/49733
dc.description.abstract
Haem-oxygenase-1 (HO-1) is an enzyme responsible for the degradation of haem that can suppress inflammation, through the production of carbon monoxide (CO). It has been shown in several experimental models that genetic and pharmacological induction of HO-1, as well as non-toxic administration of CO, can reduce inflammatory diseases, such as endotoxic shock, type 1 diabetes and graft rejection. Recently, it was shown that the HO-1/CO system can alter the function of antigen-presenting cells (APCs) and reduce T-cell priming, which can be beneficial during immune-driven inflammatory diseases. The molecular mechanisms by which the HO-1 and CO reduce both APC- and T-cell-driven immunity are just beginning to be elucidated. In this article we discuss recent findings related to the immune regulatory capacity of HO-1 and CO at the level of recognition of pathogen-associated molecular patterns and T-cell priming by APCs. Finally, we propose a possible regulatory role for HO-1 and CO over the recently described mitochondria-dependent immunity. These concepts could contribute to the design of new therapeutic tools for inflammation-based diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antigen Presentation
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Carbon Monoxide
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Cytokine
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Dendritic Cells
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Haem-Oxygenase 1
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Inmunología
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dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-18T19:08:51Z
dc.journal.volume
149
dc.journal.number
1
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Riquelme, Sebastián A.. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Carreño, Leandro J.. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Espinoza, Janyra A.. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
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Fil: Alvarez Lobos, Manuel M.. Pontificia Universidad Católica de Chile; Chile
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Fil: Riedel, Claudia. Universidad Andrés Bello; Chile
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Fil: Bueno, Susan M.. Pontificia Universidad Católica de Chile; Chile
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Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
dc.journal.title
Immunology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/imm.12605
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/imm.12605
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