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dc.contributor.author Arcos, Alexis
dc.contributor.author de Paola, Maria Matilde
dc.contributor.author Gianetti, Diego
dc.contributor.author Acuña, Diego
dc.contributor.author Velásquez, Zahady D.
dc.contributor.author Miró, María Paz
dc.contributor.author Toro, Gabriela
dc.contributor.author Hinrichsen, Bryan
dc.contributor.author Muñoz, Rosa Iris
dc.contributor.author Lin, Yimo
dc.contributor.author Mardones, Gonzalo A.
dc.contributor.author Ehrenfeld, Pamela
dc.contributor.author Rivera, Francisco J.
dc.contributor.author Michaut, Marcela Alejandra
dc.contributor.author Batiz, Luis Federico
dc.date.available 2018-06-22T17:57:02Z
dc.date.issued 2017-12
dc.identifier.citation Arcos, Alexis; de Paola, Maria Matilde; Gianetti, Diego; Acuña, Diego; Velásquez, Zahady D.; et al.; α-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility; Nature Publishing Group; Scientific Reports; 7; 1; 12-2017; 1-14
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/11336/49678
dc.description.abstract The balance between ovarian folliculogenesis and follicular atresia is critical for female fertility and is strictly regulated by a complex network of neuroendocrine and intra-ovarian signals. Despite the numerous functions executed by granulosa cells (GCs) in ovarian physiology, the role of multifunctional proteins able to simultaneously coordinate/modulate several cellular pathways is unclear. Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (α-SNAP) is a multifunctional protein that participates in SNARE-mediated membrane fusion events. In addition, it regulates cell-to-cell adhesion, AMPK signaling, autophagy and apoptosis in different cell types. In this study we examined the expression pattern of α-SNAP in ovarian tissue and the consequences of α-SNAP (M105I) mutation (hyh mutation) in folliculogenesis and female fertility. Our results showed that α-SNAP protein is highly expressed in GCs and its expression is modulated by gonadotropin stimuli. On the other hand, α-SNAP-mutant mice show a reduction in α-SNAP protein levels. Moreover, increased apoptosis of GCs and follicular atresia, reduced ovulation rate, and a dramatic decline in fertility is observed in α-SNAP-mutant females. In conclusion, α-SNAP plays a critical role in the balance between follicular development and atresia. Consequently, a reduction in its expression/function (M105I mutation) causes early depletion of ovarian follicles and female subfertility.
dc.format application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject α-SNAP
dc.subject ovarian granulosa cells
dc.subject folliculogenesis
dc.subject female fertility
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title α-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-06-13T17:50:53Z
dc.journal.volume 7
dc.journal.number 1
dc.journal.pagination 1-14
dc.journal.pais Reino Unido
dc.journal.ciudad Londres
dc.description.fil Fil: Arcos, Alexis. Universidad Austral de Chile; Chile
dc.description.fil Fil: de Paola, Maria Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil Fil: Gianetti, Diego. Universidad Austral de Chile; Chile
dc.description.fil Fil: Acuña, Diego. Universidad Austral de Chile; Chile
dc.description.fil Fil: Velásquez, Zahady D.. Universidad Austral de Chile; Chile
dc.description.fil Fil: Miró, María Paz. Universidad Austral de Chile; Chile
dc.description.fil Fil: Toro, Gabriela. Universidad Austral de Chile; Chile
dc.description.fil Fil: Hinrichsen, Bryan. Universidad Austral de Chile; Chile
dc.description.fil Fil: Muñoz, Rosa Iris. Universidad Austral de Chile; Chile
dc.description.fil Fil: Lin, Yimo. Oregon Health and Science University; Estados Unidos
dc.description.fil Fil: Mardones, Gonzalo A.. Universidad Austral de Chile; Chile
dc.description.fil Fil: Ehrenfeld, Pamela. Universidad Austral de Chile; Chile
dc.description.fil Fil: Rivera, Francisco J.. Paracelsus Medizinische Privatuniversitat; Austria. Universidad Austral de Chile; Chile
dc.description.fil Fil: Michaut, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil Fil: Batiz, Luis Federico. Universidad Austral de Chile; Chile. Universidad de los Andes; Venezuela
dc.journal.title Scientific Reports
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-017-12292-9
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-12292-9
dc.conicet.fuente Elsevier


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  • Articulos(IMBECU) [182]
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    Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS

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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)