Mostrar el registro sencillo del ítem

dc.contributor.author
Arcos, Alexis
dc.contributor.author
de Paola, Maria Matilde
dc.contributor.author
Gianetti, Diego
dc.contributor.author
Acuña, Diego
dc.contributor.author
Velásquez, Zahady D.
dc.contributor.author
Miró, María Paz
dc.contributor.author
Toro, Gabriela
dc.contributor.author
Hinrichsen, Bryan
dc.contributor.author
Muñoz, Rosa Iris
dc.contributor.author
Lin, Yimo
dc.contributor.author
Mardones, Gonzalo A.
dc.contributor.author
Ehrenfeld, Pamela
dc.contributor.author
Rivera, Francisco J.
dc.contributor.author
Michaut, Marcela Alejandra
dc.contributor.author
Batiz, Luis Federico
dc.date.available
2018-06-22T17:57:02Z
dc.date.issued
2017-12
dc.identifier.citation
Arcos, Alexis; de Paola, Maria Matilde; Gianetti, Diego; Acuña, Diego; Velásquez, Zahady D.; et al.; α-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility; Nature Publishing Group; Scientific Reports; 7; 1; 12-2017; 1-14
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/49678
dc.description.abstract
The balance between ovarian folliculogenesis and follicular atresia is critical for female fertility and is strictly regulated by a complex network of neuroendocrine and intra-ovarian signals. Despite the numerous functions executed by granulosa cells (GCs) in ovarian physiology, the role of multifunctional proteins able to simultaneously coordinate/modulate several cellular pathways is unclear. Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (α-SNAP) is a multifunctional protein that participates in SNARE-mediated membrane fusion events. In addition, it regulates cell-to-cell adhesion, AMPK signaling, autophagy and apoptosis in different cell types. In this study we examined the expression pattern of α-SNAP in ovarian tissue and the consequences of α-SNAP (M105I) mutation (hyh mutation) in folliculogenesis and female fertility. Our results showed that α-SNAP protein is highly expressed in GCs and its expression is modulated by gonadotropin stimuli. On the other hand, α-SNAP-mutant mice show a reduction in α-SNAP protein levels. Moreover, increased apoptosis of GCs and follicular atresia, reduced ovulation rate, and a dramatic decline in fertility is observed in α-SNAP-mutant females. In conclusion, α-SNAP plays a critical role in the balance between follicular development and atresia. Consequently, a reduction in its expression/function (M105I mutation) causes early depletion of ovarian follicles and female subfertility.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Α-Snap
dc.subject
Ovarian Granulosa Cells
dc.subject
Folliculogenesis
dc.subject
Female Fertility
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
α-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T17:50:53Z
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
1-14
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Arcos, Alexis. Universidad Austral de Chile; Chile
dc.description.fil
Fil: de Paola, Maria Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Gianetti, Diego. Universidad Austral de Chile; Chile
dc.description.fil
Fil: Acuña, Diego. Universidad Austral de Chile; Chile
dc.description.fil
Fil: Velásquez, Zahady D.. Universidad Austral de Chile; Chile
dc.description.fil
Fil: Miró, María Paz. Universidad Austral de Chile; Chile
dc.description.fil
Fil: Toro, Gabriela. Universidad Austral de Chile; Chile
dc.description.fil
Fil: Hinrichsen, Bryan. Universidad Austral de Chile; Chile
dc.description.fil
Fil: Muñoz, Rosa Iris. Universidad Austral de Chile; Chile
dc.description.fil
Fil: Lin, Yimo. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Mardones, Gonzalo A.. Universidad Austral de Chile; Chile
dc.description.fil
Fil: Ehrenfeld, Pamela. Universidad Austral de Chile; Chile
dc.description.fil
Fil: Rivera, Francisco J.. Paracelsus Medizinische Privatuniversitat; Austria. Universidad Austral de Chile; Chile
dc.description.fil
Fil: Michaut, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Batiz, Luis Federico. Universidad Austral de Chile; Chile. Universidad de los Andes; Venezuela
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-017-12292-9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-12292-9


Archivos asociados

 

Comunidades y colecciones

  • Articulos(IMBECU) [282]
    Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
  • Articulos(IHEM) [180]
    Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS

Mostrar el registro sencillo del ítem