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dc.contributor.author
Molinuevo, María Silvina  
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Fernández, Juan Manuel  
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Cortizo, Ana María  
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McCarthy, Antonio Desmond  
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Schurman, León  
dc.contributor.author
Sedlinsky, Claudia  
dc.date.available
2018-06-21T15:29:38Z  
dc.date.issued
2017-07  
dc.identifier.citation
Molinuevo, María Silvina; Fernández, Juan Manuel; Cortizo, Ana María; McCarthy, Antonio Desmond; Schurman, León; et al.; Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: Preventive role of vitamin D; Elsevier Ireland; Molecular and Cellular Endocrinology; 450; 7-2017; 94-104  
dc.identifier.issn
0303-7207  
dc.identifier.uri
http://hdl.handle.net/11336/49541  
dc.description.abstract
Advanced glycation end products (AGE) have been demonstrated to induce the osteogenic trans-differentiation of vascular smooth muscle cells (VSMC). Strontium ranelate (SR) is an anti-osteoporotic agent that has both anti-catabolic and anabolic actions on bone tissue. However, in the last years SR has been associated with an increase of cardiovascular risk. We hypothesize that SR can increase the osteoblastic trans-differentiation of VSMC and the induction of extracellular calcifications, an effect that could be potentiated in the presence of AGE and inhibited by simultaneous administration of vitamin D. The present results of our in vitro experiments demonstrate that AGE and SR alone or in combination, stimulate L-type calcium channels, causing an increase in reactive oxygen species and activation of both ERK and NFkB, with the final effect of promoting the osteogenic shift of VSMC. Importantly, these in vitro effects of AGE and/or SR can be prevented by co-incubation with vitamin D.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Ireland  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Advanced Glycation End Products  
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Osteoblasts  
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Strontium Ranelate  
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Vascular Smooth Muscle Cells  
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Vitamin D  
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Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: Preventive role of vitamin D  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-21T12:57:20Z  
dc.journal.volume
450  
dc.journal.pagination
94-104  
dc.journal.pais
Irlanda  
dc.journal.ciudad
Limerick  
dc.description.fil
Fil: Molinuevo, María Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina  
dc.description.fil
Fil: Fernández, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina  
dc.description.fil
Fil: Cortizo, Ana María. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina  
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Fil: McCarthy, Antonio Desmond. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina  
dc.description.fil
Fil: Schurman, León. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina  
dc.description.fil
Fil: Sedlinsky, Claudia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina  
dc.journal.title
Molecular and Cellular Endocrinology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.mce.2017.04.022  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720717302459