Mostrar el registro sencillo del ítem
dc.contributor.author
Brea, María Soledad
dc.contributor.author
Morgan, Patricio Eduardo
dc.contributor.author
Perez, Nestor Gustavo
dc.date.available
2018-06-20T01:41:02Z
dc.date.issued
2017-06-12
dc.identifier.citation
Brea, María Soledad; Morgan, Patricio Eduardo; Perez, Nestor Gustavo; Intramyocardial gene silencing by interfering RNA; Allied Academies; Journal of RNA and Genomics; 13; 1; 12-6-2017; 550-556
dc.identifier.issn
1747-0854
dc.identifier.uri
http://hdl.handle.net/11336/49492
dc.description.abstract
RNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studiedin recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascular diseases havea high incidence in the current population, and despite of the extensive research, safe and efficient therapeutics have notyet been found, which is reflected by 17.1 million people who die each year for this cause. In this context, siRNAs arebeing considered a therapeutic tool to regulate the expression of genes involved in the generation of these pathologies.The efficacy of siRNAs entry to cardiomyocytes, the safety of the delivery process and the degree of silencing achievedare main aspects before consider it as a cardiovascular disease therapy. Presently, we will give a brief outline of thecurrent understanding of the RNAi mechanism and the delivery system to the heart. We describe the use of lentivirus fora functional silencing of cardiac proteins in the study of a pathophysiological process, the slow force response to cardiacstretch.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Allied Academies
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sirna
dc.subject
Heart
dc.subject
Lentivirus
dc.subject
Cardiomyocyte
dc.subject.classification
Fisiología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Sistemas Cardíaco y Cardiovascular
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Intramyocardial gene silencing by interfering RNA
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-08T14:27:24Z
dc.journal.volume
13
dc.journal.number
1
dc.journal.pagination
550-556
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Brea, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina
dc.description.fil
Fil: Morgan, Patricio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina
dc.description.fil
Fil: Perez, Nestor Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina
dc.journal.title
Journal of RNA and Genomics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.alliedacademies.org/articles/intramyocardial-gene-silencing-by-interfering-rna-7644.ht
Archivos asociados