Artículo
INGAP-PP effects on β-cell mass and function are related to its positive effect on islet angiogenesis and VEGFA production
Román, Carolina Lisi
; Maiztegui, Barbara
; del Zotto, Hector Herminio
; Gagliardino, Juan Jose
; Flores, Luis Emilio
Fecha de publicación:
10/2017
Editorial:
Elsevier Ireland
Revista:
Molecular and Cellular Endocrinology
ISSN:
0303-7207
e-ISSN:
1872-8057
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Our aim was to determine whether islet angiogenesis and VEGFA production/release participate in the mechanism by which INGAP-PP enhances β-cell function and mass. We used two models: a) in vivo (normal rats injected with INGAP-PP for 10 days) and b) in vitro (normal islets cultured for 4 days with INGAP-PP, VEGFA, Rapamycin, and the specific VEGF-Receptor inhibitor, SU5416). INGAP-PP administration enhanced insulin secretion, β-cell mass, islet vascularization, and angiogenesis without affecting glucose homeostasis. Normal islets cultured with INGAP-PP and VEGFA increased insulin and VEGFA secretion while apoptosis decreased. INGAP-PP-induced effects were prevented by both Rapamycin and SU5416. INGAP-PP effects on β-cell mass and function were significantly associated with a positive effect on islet angiogenesis and VEGFA production/release. VEGF-A possibly potentiates INGAP-PP effect through mTORC pathway.
Palabras clave:
Angiogenesis
,
Diabetes
,
Insulin Secretion
,
Islet Cells
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Articulos(CENEXA)
Articulos de CENTRO DE ENDOCRINOLOGIA EXP.Y APLICADA (I)
Articulos de CENTRO DE ENDOCRINOLOGIA EXP.Y APLICADA (I)
Citación
Román, Carolina Lisi; Maiztegui, Barbara; del Zotto, Hector Herminio; Gagliardino, Juan Jose; Flores, Luis Emilio; INGAP-PP effects on β-cell mass and function are related to its positive effect on islet angiogenesis and VEGFA production; Elsevier Ireland; Molecular and Cellular Endocrinology; 470; 10-2017
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