Mostrar el registro sencillo del ítem
dc.contributor.author
Abood, Steven
dc.contributor.author
Mustafi, Sushmita
dc.contributor.author
Veisaga, Maria-Luisa
dc.contributor.author
Lopez, Luis Alberto
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Barbieri, Manuel Alejandro
dc.date.available
2018-06-19T20:15:14Z
dc.date.issued
2017-03
dc.identifier.citation
Abood, Steven; Mustafi, Sushmita; Veisaga, Maria-Luisa; Lopez, Luis Alberto; Barbieri, Manuel Alejandro; Biomedical properties of sesquiterpene lactones, with a focus on dehydroleucodine; Natural Products; Natural Product Communications; 12; 3-2017; 995-1005
dc.identifier.issn
1934-578X
dc.identifier.uri
http://hdl.handle.net/11336/49453
dc.description.abstract
Dehydroleucodine, a sesquiterpene lactone, belongs to the terpenoid class of secondary metabolites. Dehydroleucodine and other Artemisia-derivedphytochemicals evolved numerous biodefenses that were first co-opted for human pharmacological use by traditional cultures in the Middle East, Asia, Europeand the Americas. Later, these phytochemicals were modified through the use of medicinal chemical techniques to increase their potency. All sesquiterpenelactones contain an α-methylene-γ-lactone group, which confers thiol reactivity, which is responsible, in part, for their therapeutic effects. A wide range oftherapeutic uses of sequiterpene lactones has been found, including anti-adipogenic, cytoprotective, anti-microbial, anti-viral, anti-fungal, anti-malarial and,anti-migraine effects. Dehydroleucodine significantly inhibits differentiation of murine preadipocytes and also significantly decreases the accumulation oflipid content by a dramatic down regulation of adipogenic-specific transcriptional factors PPARγ and C-EBPα. Dehydroleucodine also inhibits secretion ofmatrix metalloprotease-2 (MMP-2), which is a known protease involved in migration and invasion of B16 cells. In addition to these anti-adipogenic and anticancereffects, dehydroleucodine effectively neutralizes several bacterial species, including Bacillus cereus, Staphylococcus aureus, Escherichia coli,Klebsiella pneumoniae, Helicobacter pylori, methicillin resistant Staphylococcus aueus (MRSA) and S. epidermis (MRSE). The compound also inhibits thegrowth and secretion of several toxins of Pseudomonas aeruginosa, possesses gastro-protective qualities and possesses anti-parasitic properties againstTrypanosoma cruzi, responsible for Chagas disease. Other sesquiterpene lactones, such as parthenolide, costunolide, and helanin, also possess significanttherapeutic utility.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Natural Products
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Dehydroleucodine,
dc.subject
Inflammation
dc.subject
Leukemia
dc.subject
Obesity
dc.subject.classification
Salud Ocupacional
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias de la Salud
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Biomedical properties of sesquiterpene lactones, with a focus on dehydroleucodine
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T16:55:01Z
dc.journal.volume
12
dc.journal.pagination
995-1005
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Westerville
dc.description.fil
Fil: Abood, Steven. Florida International University; Estados Unidos
dc.description.fil
Fil: Mustafi, Sushmita. Florida International University; Estados Unidos
dc.description.fil
Fil: Veisaga, Maria-Luisa. Florida International University; Estados Unidos
dc.description.fil
Fil: Lopez, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Barbieri, Manuel Alejandro. Fairchild Tropical Botanic Garden; Estados Unidos
dc.journal.title
Natural Product Communications
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1701200638
Archivos asociados