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dc.contributor.author
Giraud Billoud, Maximiliano German
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dc.contributor.author
Ezquer, Fernando
dc.contributor.author
Bahamonde, Javiera
dc.contributor.author
Ezquer, Marcelo
dc.date.available
2018-06-19T19:42:54Z
dc.date.issued
2017-01
dc.identifier.citation
Giraud Billoud, Maximiliano German; Ezquer, Fernando; Bahamonde, Javiera; Ezquer, Marcelo; Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus; Instituto de Histología y Embriología “Dr. Mario H. Burgos”; Biocell; 41; 1; 1-2017; 1-12
dc.identifier.issn
1667-5746
dc.identifier.uri
http://hdl.handle.net/11336/49428
dc.description.abstract
A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy (DN), but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the disease on both transporters in type 1 diabetes mellitus (T1DM). We used eight-week-old male C57BL/6 mice divided into two groups; one of them received the vehicle (control group), while the other received the vehicle + 200 mg/kg streptozotocin (T1DM). Ten weeks after the injection, we evaluated plasma insulin, enzymuria, urinary vitamin D-binding protein (VDBP), tubulointerstitial fibrosis and proximal tubule histology, markers of autophagy, and megalin and cubilin levels. We found a reduction in tubular protein reabsorption (albumin and VDBP as specific substances carried by both transporters) with increased tubulointerstitial injury, development of fibrosis, thickening of tubular basement membrane, and an increase in tubular cell metalloproteases. This was associated with a decrease in the renal expression of megalin and cubilin. We also observed an increase in the amount of cellular vesicles of the phagocytic system in the tubules, which could be linked to an alteration of normal intracellular trafficking of both receptors, thus affecting the normal function of transporters in early stages of DN. In diabetic animals, the added effects of tubulointerstitial injury, the decreases in megalin and cubilin expression, and an altered intracellular trafficking of these receptors, seriously affect protein reabsorption
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Instituto de Histología y Embriología “Dr. Mario H. Burgos”
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Albuminuria
dc.subject
Megalin
dc.subject
Cubilin
dc.subject
Autophagy
dc.subject.classification
Medicina Critica y de Emergencia
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T16:54:22Z
dc.identifier.eissn
0327-9545
dc.journal.volume
41
dc.journal.number
1
dc.journal.pagination
1-12
dc.journal.pais
Argentina
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dc.journal.ciudad
Mendoza
dc.description.fil
Fil: Giraud Billoud, Maximiliano German. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Ezquer, Fernando. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
dc.description.fil
Fil: Bahamonde, Javiera. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
dc.description.fil
Fil: Ezquer, Marcelo. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
dc.journal.title
Biocell
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.cricyt.edu.ar/biocell/vol/41_I_1.html
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