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dc.contributor.author
Blandón, Lina M.
dc.contributor.author
Islan, German Abel
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Castro, Guillermo Raul
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Noseda, Miguel D.
dc.contributor.author
Thomaz Soccol, Vanete
dc.contributor.author
Soccol, Carlos R.
dc.date.available
2018-06-19T18:42:30Z
dc.date.issued
2016-09
dc.identifier.citation
Blandón, Lina M.; Islan, German Abel; Castro, Guillermo Raul; Noseda, Miguel D.; Thomaz Soccol, Vanete; et al.; Kefiran-alginate gel microspheres for oral delivery of ciprofloxacin; Elsevier Science; Colloids and Surfaces B: Biointerfaces; 145; 9-2016; 706-715
dc.identifier.issn
0927-7765
dc.identifier.uri
http://hdl.handle.net/11336/49378
dc.description.abstract
Ciprofloxacin is a broad-spectrum antibiotic associated with gastric and intestinal side effects after extended oral administration. Alginate is a biopolymer commonly employed in gel synthesis by ionotropic gelation, but unstable in the presence of biological metal-chelating compounds and/or under dried conditions. Kefiran is a microbial biopolymer able to form gels with the advantage of displaying antimicrobial activity. In the present study, kefiran-alginate gel microspheres were developed to encapsulate ciprofloxacin for antimicrobial controlled release and enhanced bactericidal effect against common pathogens. Scanning electron microscopy (SEM) analysis of the hybrid gel microspheres showed a spherical structure with a smoother surface compared to alginate gel matrices. In vitro release of ciprofloxacin from kefiran-alginate microspheres was less than 3.0% and 5.0% at pH 1.2 (stomach), and 5.0% and 25.0% at pH 7.4 (intestine) in 3 and 21 h, respectively. Fourier transform infrared spectroscopy (FTIR) of ciprofloxacin-kefiran showed the displacement of typical bands of ciprofloxacin and kefiran, suggesting a cooperative interaction by hydrogen bridges between both molecules. Additionally, the thermal analysis of ciprofloxacin-kefiran showed a protective effect of the biopolymer against ciprofloxacin degradation at high temperatures. Finally, antimicrobial assays of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhymurium, and Staphylococcus aureus demonstrated the synergic effect between ciprofloxacin and kefiran against the tested microorganisms.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Alginate
dc.subject
Antimicrobial Activity
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Ciprofloxacin
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Controlled Release
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Hybrid Gel Microspheres
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Kefiran
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Kefiran-Ciprofloxacin Complex
dc.subject.classification
Otras Biotecnologías de la Salud
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Biotecnología de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Kefiran-alginate gel microspheres for oral delivery of ciprofloxacin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-19T16:52:57Z
dc.journal.volume
145
dc.journal.pagination
706-715
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Blandón, Lina M.. Universidade Federal do Paraná; Brasil
dc.description.fil
Fil: Islan, German Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
dc.description.fil
Fil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
dc.description.fil
Fil: Noseda, Miguel D.. Universidade Federal do Paraná; Brasil
dc.description.fil
Fil: Thomaz Soccol, Vanete. Universidade Federal do Paraná; Brasil
dc.description.fil
Fil: Soccol, Carlos R.. Universidade Federal do Paraná; Brasil
dc.journal.title
Colloids and Surfaces B: Biointerfaces
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.colsurfb.2016.05.078
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0927776516304155
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