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dc.contributor.author
Sexton, Jane E.
dc.contributor.author
Desmonds, Terri
dc.contributor.author
Quick, Kathryn
dc.contributor.author
Taylor, Ruth
dc.contributor.author
Abramowitz, Joel
dc.contributor.author
Forge, Andy
dc.contributor.author
Kros, Corné J.
dc.contributor.author
Birnbaumer, Lutz
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dc.contributor.author
Wood, John N.
dc.date.available
2018-06-19T18:03:00Z
dc.date.issued
2016-01
dc.identifier.citation
Sexton, Jane E.; Desmonds, Terri; Quick, Kathryn; Taylor, Ruth; Abramowitz, Joel; et al.; The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing; Elsevier Ireland; Neuroscience Letters; 610; 1-2016; 36-42
dc.identifier.issn
0304-3940
dc.identifier.uri
http://hdl.handle.net/11336/49344
dc.description.abstract
Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features of TRP channels include their high structural homology and their propensity to form heteromeric complexes which suggests potential functional redundancy. We previously showed that TRPC3 and TRPC6 double knockout animals have deficits in light touch and hearing whilst single knockouts were apparently normal. We have extended these studies to analyse deficits in global quadruple TRPC1, 3, 5 and 6 null mutant mice. We examined both touch and hearing in behavioural and electrophysiological assays, and provide evidence that the quadruple knockout mice have larger deficits than the TRPC3 TRPC6 double knockouts. Mechano-electrical transducer currents of cochlear outer hair cells were however normal. This suggests that TRPC1, TRPC3, TRPC5 and TRPC6 channels contribute to cutaneous and auditory mechanosensation in a combinatorial manner, but have no direct role in cochlear mechanotransduction.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Mechanosensation
dc.subject
Touch
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Trp Channels
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Dko
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Double Knockout Mice
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Quadko
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Quadruple Knockout Mice
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-19T16:52:49Z
dc.journal.volume
610
dc.journal.pagination
36-42
dc.journal.pais
Irlanda
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dc.journal.ciudad
Shannon
dc.description.fil
Fil: Sexton, Jane E.. University College London; Reino Unido
dc.description.fil
Fil: Desmonds, Terri. University of Sussex; Reino Unido
dc.description.fil
Fil: Quick, Kathryn. University College London; Reino Unido
dc.description.fil
Fil: Taylor, Ruth. University College London; Reino Unido
dc.description.fil
Fil: Abramowitz, Joel. National Institute of Environmental Health Sciences; Estados Unidos
dc.description.fil
Fil: Forge, Andy. University College London; Reino Unido
dc.description.fil
Fil: Kros, Corné J.. University of Sussex; Reino Unido. University of Groningen; Países Bajos
dc.description.fil
Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. National Institute of Environmental Health Sciences; Estados Unidos
dc.description.fil
Fil: Wood, John N.. University College London; Reino Unido
dc.journal.title
Neuroscience Letters
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304394015302159
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neulet.2015.10.052
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683096/
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