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dc.contributor.author
Bresciani, Anne Gøther
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dc.contributor.author
Paul, Sinu
dc.contributor.author
Schommer, Nina
dc.contributor.author
Dillon, Myles B.
dc.contributor.author
Bancroft, Tara
dc.contributor.author
Greenbaum, Jason
dc.contributor.author
Sette, Alessandro
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dc.contributor.author
Nielsen, Morten
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dc.contributor.author
Peters, Bjoern
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dc.date.available
2018-06-19T17:29:19Z
dc.date.issued
2016-05
dc.identifier.citation
Bresciani, Anne Gøther; Paul, Sinu; Schommer, Nina; Dillon, Myles B.; Bancroft, Tara; et al.; T-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome; Wiley Blackwell Publishing, Inc; Immunology; 148; 1; 5-2016; 34-39
dc.identifier.issn
0019-2805
dc.identifier.uri
http://hdl.handle.net/11336/49324
dc.description.abstract
Several mechanisms exist to avoid or suppress inflammatory T-cell immune responses that could prove harmful to the host due to targeting self-antigens or commensal microbes. We hypothesized that these mechanisms could become evident when comparing the immunogenicity of a peptide from a pathogen or allergen with the conservation of its sequence in the human proteome or the healthy human microbiome. Indeed, performing such comparisons on large sets of validated T-cell epitopes, we found that epitopes that are similar with self-antigens above a certain threshold showed lower immunogenicity, presumably as a result of negative selection of T cells capable of recognizing such peptides. Moreover, we also found a reduced level of immune recognition for epitopes conserved in the commensal microbiome, presumably as a result of peripheral tolerance. These findings indicate that the existence (and potentially the polarization) of T-cell responses to a given epitope is influenced and to some extent predictable based on its similarity to self-antigens and commensal antigens.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Bioinformatics
dc.subject
Epitopes
dc.subject
T-Cell Recognition
dc.subject.classification
Salud Ocupacional
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
T-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-19T16:52:39Z
dc.journal.volume
148
dc.journal.number
1
dc.journal.pagination
34-39
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Bresciani, Anne Gøther. Technical University of Denmark; Dinamarca. La Jolla Institute for Allergy and Immunology; Estados Unidos
dc.description.fil
Fil: Paul, Sinu. La Jolla Institute for Allergy and Immunology; Estados Unidos
dc.description.fil
Fil: Schommer, Nina. La Jolla Institute for Allergy and Immunology; Estados Unidos
dc.description.fil
Fil: Dillon, Myles B.. La Jolla Institute for Allergy and Immunology; Estados Unidos
dc.description.fil
Fil: Bancroft, Tara. La Jolla Institute for Allergy and Immunology; Estados Unidos
dc.description.fil
Fil: Greenbaum, Jason. La Jolla Institute for Allergy and Immunology; Estados Unidos
dc.description.fil
Fil: Sette, Alessandro. La Jolla Institute for Allergy and Immunology; Estados Unidos
dc.description.fil
Fil: Nielsen, Morten. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentina. Technical University of Denmark; Dinamarca
dc.description.fil
Fil: Peters, Bjoern. La Jolla Institute for Allergy and Immunology; Estados Unidos
dc.journal.title
Immunology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/imm.12585
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/imm.12585
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