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dc.contributor.author
Legnoverde, María Soledad
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Jiménez Morales, Ignacio
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Jiménez-Morales, Alberto
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Rodríguez Castellón, Enrique
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Basaldella, Elena Isabel
dc.date.available
2016-03-23T17:29:27Z
dc.date.issued
2013-08
dc.identifier.citation
Legnoverde, María Soledad; Jiménez Morales, Ignacio ; Jiménez-Morales, Alberto; Rodríguez Castellón, Enrique; Basaldella, Elena Isabel; Modified silica matrices for controlled release of cephalexin; Bentham Science Publishers; Medicinal Chemistry; 9; 5; 8-2013; 672-680
dc.identifier.issn
1573-4064
dc.identifier.uri
http://hdl.handle.net/11336/4930
dc.description.abstract
SBA-15 type ordered silicas possessing amino groups attached onto their surfaces were prepared by using two different functionalization methodologies. These matrices were used for the cephalexin adsorption from aqueous solution and further kinetic study of its release into physiological solution. The materials were characterized by nitrogen adsorption/ desorption, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-Ray photoelectron spectrometry (XPS) and thermo analytical methods (TG/DSC). UV–visible spectroscopy at 262 nm was used for quantitative determination of cephalexin present in liquid media. Results reveal that drug adsorption capacities and the corresponding release profiles are dependent on the number of loaded amino groups and their location, which in turn is determined by the functionalization procedure used. It was concluded that amino post-functionalization could enhance long-term cephalexin delivery in comparison with co-functionalization procedure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sba-15
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Mesoporous Silicas
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Surface Functionalization
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Drug Adsorption
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Ingeniería de los Materiales
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Modified silica matrices for controlled release of cephalexin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1875-6638
dc.journal.volume
9
dc.journal.number
5
dc.journal.pagination
672-680
dc.journal.pais
Emiratos Árabes Unidos
dc.journal.ciudad
Sharjah
dc.description.fil
Fil: Legnoverde, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Ciencias Aplicadas; Argentina. Universidad Tecnologica Nacional. Facultad Reional La Plata. Centro de Investigación y Desarrollo en Ciencia y Tecnologia de Materiales; Argentina
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Fil: Jiménez Morales, Ignacio . Universidad de Málaga. Facultad de Ciencias. Unidad asociada al Instituto de Catálisis. Departamento de Química Inorganica; España
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Fil: Jiménez-Morales, Alberto. Hospital Virgen de las Nieves. Servicio de Farmacia; España
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Fil: Rodríguez Castellón, Enrique. Universidad de Málaga. Facultad de Ciencias. Unidad asociada al Instituto de Catálisis. Departamento de Química Inorganica; España
dc.description.fil
Fil: Basaldella, Elena Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Ciencias Aplicadas; Argentina. Universidad Tecnologica Nacional. Facultad Reional La Plata. Centro de Investigacion y Desarrollo en Ciencia y Tecnologia de Materiales; Argentina
dc.journal.title
Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/contentone/ben/mc/2013/00000009/00000005/art00006
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1573406411309050006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/111602/article
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.2174/1573406411309050006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/23061564
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